Exposure | Myeloid leukaemia | Lymphoid leukaemia | ||||||
---|---|---|---|---|---|---|---|---|
Cases, n (%) | Non-cases, n (%) | Multivariate HR (95% CI) | p Value* | Cases, n (%) | Non-cases, n (%) | Multivariate HR (95% CI) | p Value* | |
Pesticides | ||||||||
No | 140 (78.21) | 174 998 (82.16) | 1.00 | 0.15 | 182 (80.89) | 174 998 (82.16) | 1.00 | 0.71 |
Low | 19 (10.61) | 16 790 (7.88) | 1.34 (0.81 to 2.21) | 21 (9.33) | 16 790 (7.88) | 1.01 (0.62 to 1.64) | ||
High | 20 (11.17) | 21 199 (9.95) | 1.36 (0.82 to 2.25) | 22 (9.78) | 21 199 (9.95) | 1.10 (0.69 to 1.77) | ||
Herbicides | ||||||||
No | 144 (81.36) | 177 669 (83.95) | 1.00 | 0.23 | 187 (83.86) | 177 669 (83.95) | 1.00 | 0.93 |
Low | – | – | – | – | – | – | ||
High | 33 (18.64) | 33 971 (16.05) | 1.29 (0.85 to 1.96) | 36 (16.14) | 33 971 (16.05) | 1.02 (0.68–1.51) | ||
Insecticides | ||||||||
No | 140 (78.21) | 174 998 (82.16) | 1.00 | 0.15 | 182 (80.89) | 174 998 (82.16) | 1.00 | 0.71 |
Low | 19 (10.61) | 16 790 (7.88) | 1.34 (0.81 to 2.21) | 21 (9.33) | 16 790 (7.88) | 1.01 (0.62 to 1.64) | ||
High | 20 (11.17) | 21 199 (9.95) | 1.36 (0.82 to 2.25) | 22 (9.78) | 21 199 (9.95) | 1.10 (0.69 to 1.77) | ||
Aromatic solvents | ||||||||
No | 99 (55.31) | 129 639 (60.85) | 1.00 | 0.26 | 130 (57.78) | 129 639 (60.85) | 1.00 | 0.34 |
Low | 68 (37.99) | 75 737 (35.55) | 1.05 (0.75 to 1.48) | 88 (39.11) | 75 737 (35.55) | 0.94 (0.69 to 1.27) | ||
High | 12 (6.70) | 7669 (3.60) | 1.61 (0.87 to 2.98) | 7 (3.11) | 7669 (3.60) | 0.65 (0.30–1.41) | ||
Benzene | ||||||||
No | 123 (68.72) | 158 884 (74.59) | 1.00 | 0.08 | 166 (73.78) | 158 884 (74.59) | 1.00 | 0.22 |
Low | 39 (21.79) | 42 987 (20.18) | 1.15 (0.78 to 1.70) | 51 (22.67) | 42 987 (20.18) | 1.06 (0.75 to 1.50) | ||
High | 17 (9.50) | 11 140 (5.23) | 1.60 (0.95 to 2.69) | 8 (3.56) | 11 140 (5.23) | 0.52 (0.25 to 1.06) | ||
Chlorinated solvents | ||||||||
No | 95 (53.07) | 121 074 (56.82) | 1.00 | 0.76 | 121 (53.78) | 121 074 (56.82) | 1.00 | 0.60 |
Low | 78 (43.58) | 86 853 (40.76) | 1.02 (0.75 to 1.40) | 99 (44.00) | 86 853 (40.76) | 0.95 (0.72 to 1.25) | ||
High | 6 (3.35) | 5138 (2.41) | 1.20 (0.51 to 2.80) | 5 (2.22) | 5138 (2.41) | 0.80 (0.32 to 1.99) | ||
Trichloroethylene | ||||||||
No | 104 (58.10) | 129 219 (60.65) | 1.00 | 0.58 | 132 (58.67) | 129 219 (60.65) | 1.00 | 0.36 |
Low | 70 (39.11) | 75 975 (35.66) | 1.02 (0.74–1.39) | 85 (37.78) | 75 975 (35.66) | 0.91 (0.68 to 1.20) | ||
High | 5 (2.79) | 7865 (3.69) | 0.60 (0.24 to 1.51) | 8 (3.56) | 7865 (3.69) | 0.76 (0.37 to 1.59) | ||
Formaldehyde | ||||||||
No | 130 (72.63) | 153 771 (72.19) | 1.00 | 0.73 | 158 (70.22) | 153 771 (72.19) | 1.00 | 0.50 |
Low | 49 (27.37) | 57 590 (27.04) | 1.02 (0.73 to 1.42) | 64 (28.44) | 57 590 (27.04) | 1.08 (0.81 to 1.45) | ||
High | – | 1657 (0.78) | – | 3 (1.33) | 1657 (0.78) | 1.38 (0.44 to 4.35) | ||
Metals | ||||||||
No | 127 (70.95) | 159 149 (74.72) | 1.00 | 0.78 | 156 (69.33) | 159 149 (74.72) | 1.00 | 0.42 |
Low | 41 (22.91) | 43 547 (20.45) | 0.89 (0.61 to 1.31) | 59 (26.22) | 43 547 (20.45) | 0.92 (0.66 to 1.29) | ||
High | 11 (6.15) | 10 290 (4.83) | 1.02 (0.54 to 1.96) | 10 (4.44) | 10 290 (4.83) | 0.77 (0.40 to 1.49) | ||
Contact with animals or animal products | ||||||||
No | 139 (77.65) | 166 818 (78.32) | 1.00 | 0.51 | 177 (78.67) | 166 818 (78.32) | 1.00 | 0.89 |
Low | 7 (3.91) | 10 014 (4.70) | 0.99 (0.46 to 2.14) | 9 (4.00) | 10 014 (4.70) | 0.99 (0.50 to 1.95) | ||
High | 33 (18.44) | 36 159 (16.98) | 1.16 (0.77 to 1.75) | 39 (17.33) | 36 159 (16.98) | 1.03 (0.70 to 1.51) | ||
Ionising radiation | ||||||||
No | 166 (92.74) | 189 422 (88.95) | 1.00 | 0.15 | 197 (87.56) | 189 422 (88.95) | 1.00 | 0.31 |
Low | 13 (7.26) | 23 062 (10.83) | 0.69 (0.39 to 1.23) | 28 (12.44) | 23 062 (10.83) | 1.32 (0.87 to 1.97) | ||
High | – | 461 (0.22) | – | – | 461 (0.22) | – |
Multivariate analyses were adjusted for sex, smoking status, alcohol intake, age at recruitment and country.
*Tests of linear trend across categories were conducted by fitting a model treating the different tertile categories as a single ordinal variable.