Estimated cumulative chlorinated solvent exposure (ppm-years) and risk of glioma, according to respondent status, excluding unexposed participants
| Chlorinated solvents* | Including proxy-only interviews | Excluding proxy-only interviews | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | OR†‡ | 95% CI | Cases | Controls | OR†‡ | 95% CI | |||||||||
| Mean | SD | N§ | Mean | SD | N§ | Mean | SD | N§ | Mean | SD | N§ | |||||
| Carbon tetrachloride | 18.3 | 45.7 | 263 | 19.5 | 54.0 | 442 | 0.97 | 0.90 to 1.05 | 17.7 | 50.1 | 141 | 19.0 | 53.7 | 428 | 0.97 | 0.88 to 1.07 |
| Chloroform | 30.1 | 73.8 | 275 | 31.7 | 89.9 | 458 | 0.98 | 0.91 to 1.06 | 28.7 | 77.0 | 153 | 30.8 | 89.1 | 446 | 0.98 | 0.89 to 1.08 |
| Methylene chloride | 78.9 | 195.0 | 304 | 71.8 | 193.5 | 490 | 0.96 | 0.89 to 1.03 | 80.0 | 222.2 | 169 | 70.2 | 192.2 | 475 | 0.96 | 0.87 to 1.05 |
| Tetrachloroethylene | 3.5 | 8.4 | 299 | 3.1 | 8.3 | 500 | 0.99 | 0.93 to 1.07 | 3.5 | 9.5 | 166 | 3.1 | 8.2 | 483 | 1.01 | 0.92 to 1.10 |
| Trichloroethane | 20.7 | 53.9 | 304 | 20.6 | 60.2 | 503 | 0.97 | 0.90 to 1.04 | 21.1 | 58.6 | 173 | 20.3 | 59.9 | 491 | 0.96 | 0.88 to 1.05 |
| Trichloroethylene | 85.9 | 333.5 | 302 | 98.9 | 441.3 | 515 | 1.02 | 0.95 to 1.10 | 84.0 | 304.3 | 164 | 91.3 | 424.5 | 499 | 1.05 | 0.95 to 1.16 |
*For all six solvents, median and minimum estimated cumulative exposure are 0.
†Adjusted for frequency matching variables (age group, sex) and age and education.
‡OR for a 1-unit increase in natural-log transformed exposures in ppm-years –10 was assigned to log (ppm-years) for those with 0 ppm-years.
§Number of participants estimated to have been exposed, among all participants.