Categories of pack-years | Never/ever smoking | |||

Independent variables | Coefficient (95% CI) | Independent variables | Coefficient (95% CI) | |

Model 1 | ||||

Log β2-mU (μg/g CrU) | Log CdU (μg/g CrU) | 0.120 (0.022 to 0.218) | Log CdU (μg/g CrU) | 0.120 (0.022 to 0.219) |

Gender | −0.101 (−0.217 to 0.014) | |||

Model 1 with β2-mU>20 μg/g CrU | ||||

Log β2-mU (μg/g CrU) | Log CdU (μg/g CrU) | 0.166 (0.090 to 0.243) | Log CdU (μg/g CrU) | 0.177 (0.100 to 0.253) |

Category of pack-years (high) | 0.166 (0.025 to 0.308) | |||

Model 2 | ||||

Log β2-mU (μg/g CrU) | Log CdU (μg/g CrU) CrU adjusted | 0.083 (−0.006 to 0.173) | Log CdU (μg/g CrU) CrU adjusted | 0.078 (−0.005 to 0.174) |

Log CrU (g/l) | −0.937 (−1.113 to −0.760) | Log CrU (g/l) | −0.907 (−1.02 to −0.429) | |

Model 2 with β2-mU>20 μg/g CrU | ||||

Log β2-mU (μg/g CrU) | Log CdU (μg/g CrU) CrU adjusted | 0.150 (0.078 to 0.222) | Log CdU (μg/g CrU) CrU adjusted | 0.153 (0.091 to 0.215) |

Log CrU (g/l) | −0.638 (−0.777 to −0.498) | Log CrU (g/l) | −0.614 (−0.706 to −0.249) | |

Category of pack-years (high) | 0.144 (0.017 to 0.271) | |||

Model 3 | ||||

Log β2-mU (μg/l) | Log CdU (μg/l) | 0.083 (−0.001 to 0.177) | Log CdU (μg/g CrU) | 0.088 (−0.001 to 0.177) |

Model 3 with β2-mU>20 μg/g CrU | ||||

Log β2-mU (μg/l) | Log CdU (μg/l) | 0.150 (0.078 to 0.222) | Log CdU (μg/l) | 0.153 (0.091 to 0.215) |

Log CrU (g/l) | 0.286 (0.135 to 0.436) | Log CrU (g/l) | 0.308 (0.179 to 0.437) | |

Category of pack-years (high) | 0.144 (0.017 to 0.271) |

The models are the same as described in table 3.

For each model, age and gender were forced in the regression.

Model 1, N=468; model 1 with β

_{2}-mU>20 μg/g CrU, N=393; models 2 and 3, N=492; models 2 and 3 with β_{2}-mU>20 μg/g CrU, N=416.β

_{2}-mU, concentration of β_{2}-microglobulin in urine; CdU, concentration of cadmium in urine; CrU, concentration of creatinine in urine.