| Cumulative exposure to MBT (mg.m−3.y) | No† | RR (95% CI) | RR (95% CI) | |||
| Adjusted for age and calendar year‡ | With additional adjustments§ | |||||
| Lung cancer¶ | ||||||
| None | 107 | 1.0 | 1.0 | |||
| 0.01–21.24 | 21 | 2.08** | (1.29 to 3.33) | 2.17** | (1.30 to 3.61) | |
| 21.25–63.74 | 4 | 0.67 | (0.25 to 1.82) | 0.65 | (0.23 to 1.81) | |
| ⩾63.75 | 4 | 1.40 | (0.51 to 3.79) | 1.44 | (0.53 to 3.96) | |
| p Value for trend†† | p = 0.30 | p = 0.38 | ||||
| Ca. large intestine‡‡ | ||||||
| None | 27 | 1.0 | 1.0 | |||
| 0.01–21.24 | 3 | 1.03 | (0.31 to 3.42) | 1.24 | (0.36 to 4.26) | |
| 21.25–63.74 | 6 | 3.98** | (1.64 to 9.67) | 4.76** | (1.82 to 12.43) | |
| ⩾63.75 | 3 | 4.05* | (1.22 to 13.45) | 4.69* | (1.38 to 15.90) | |
| p Value for trend†† | p<0.001 | p<0.001 | ||||
| Multiple myeloma§§ | ||||||
| None | 2 | 1.0 | 1.0 | |||
| 0.01–21.24 | 2 | 8.95* | (1.26 to 63.6) | 10.21* | (1.27 to 81.7) | |
| 21.25–63.74 | 2 | 18.38** | (2.59 to 130.6) | 20.57** | (2.58 to 164.0) | |
| ⩾63.75 | 0 | |||||
| p Value for trend†† | p = 0.013 | p = 0.019 | ||||
*p<0.05, **p<0.01.
†Subjects with cancer reported on death certificate or notified by cancer registry.
‡Findings adjusted for age (35–39, 40–44, 45–49, 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84 years) and calendar year (1955–1971, 1972–1981, 1982–1996, 1997–2005); findings for multiple myeloma adjusted for age only (55–59, 60–64, 65–69, 70–74, 75–79, 80–84 years).
§Findings for lung cancer adjusted for age, calendar year, duration of aniline-exposed employment (none, 0.01–4.9, ⩾5.0 years), duration of ortho-toluidine-exposed employment (none, 0.01–4.9, ⩾5.0 years), and duration of phenyl-B-naphthylamine (PBN)-exposed employment (none, 0.01–4.9, ⩾5.0 years); findings for cancer of the large intestine adjusted for age, calendar year, duration of aniline-exposed employment, and duration of PBN-exposed employment; findings for multiple myeloma adjusted for age, and duration of aniline-exposed employment.
¶ICD-8 162, ICD-9 162, ICD-10 C33, C34.
††Four exposure categories scored 1–4 and treated as a continuous measure.
‡‡ICD-8 153, ICD-9 153, ICD-10 C18.
§§ICD-8 203, ICD-9 203, ICD-10 C90.
ICD, International Classification of Diseases; RR, relative risk.