Table 4 Association between incident work-related symptoms and specific antibody levels at baseline, and changes (delta) in levels of antibodies between visits

		Lower respiratory symptoms			Rhinoconjunctivitis symptoms
		Yes	No	p Value	Yes	No	p Value
		(n = 13)	(n = 285)	p Value	(n = 19)	(n = 279)	p Value
Levels of antibody at baseline (visit 1)*
IgG	Median	0 (173)	0 (148)	0.19	0 (156)	0 (149)	0.61
IgG4	Median	0.149 (163)	0.069 (149)	0.55	0.126 (187)	0.069 (147)	0.04
IgE	Median	0.30 (179)	0.249 (148)	0.2	0.23 (151)	0.24 (149)	0.9
Changes in levels of antibodies between visits†
Delta IgG	Mean (SD)	−0.064 (0.12)	0.013 (0.123)	0.02	0.002 (0.126)	0.01 (0.124)	0.77
Delta IgG4	Mean (SD)	−0.003 (0.106)	−0.001 (0.174)	0.8	−0.108 (0.2)	−0.008 (0.168)	0.01
Delta IgE	Mean (SD)	0.120 (0.536)	−0.001 (0.143)	0.41	−0.03 (0.066)	0.006 (0.184)	0.38

*Comparisons with Mann-Whitney test; †comparisons with Student t test.