Table 1 Rates of congenital anomalies per 100 000 birth-years by categories of the landfill exposure index, unadjusted odds ratios (OR) (95% confidence intervals) and adjusted OR* (95% credible intervals)
Landfill exposure index
1234
Median (range)0 (0)0.04 (0.01–0.10)0.21 (0.11–0.38)0.68 (0.39–2.53)
Squares, n4592293278274
Births, n6 853 9131 030 3411 080 0111 165 022
All anomalies
    Rate1309.71397.41455.01454.3
    Unadjusted OR1.001.07 (1.05 to 1.09)1.11 (1.09 to 1.13)1.11 (1.09 to 1.13)
    Adjusted OR1.001.05 (0.99 to 1.10)1.08 (1.02 to 1.13)1.04 (0.99 to 1.10)
Hypospadias and epispadias
    Rate116.9117.7134.2137.6
    Unadjusted OR1.001.01 (0.95 to 1.07)1.15 (1.09 to 1.21)1.18 (1.12 to 1.24)
    Adjusted OR1.000.99 (0.90 to 1.09)1.11 (1.02 to 1.21)1.12 (1.02 to 1.22)
Neural tube defects
    Rate53.058.657.564.6
    Unadjusted OR1.001.11 (1.02 to 1.21)1.09 (1.00 to 1.18)1.22 (1.13 to 1.32)
    Adjusted OR1.001.05 (0.94 to 1.16)0.99 (0.90 to 1.09)1.09 (0.99 to 1.20)
Cardiovascular defects
    Rate80.084.9104.995.9
    Unadjusted OR1.001.06 (0.99 to 1.14)1.31 (1.23 to 1.40)1.20 (1.12 to 1.28)
    Adjusted OR1.000.97 (0.85 to 1.11)1.16 (1.00 to 1.33)1.02 (0.89 to 1.16)
Abdominal wall defects
    Rate22.425.226.126.6
    Unadjusted OR1.001.13 (0.99 to 1.28)1.16 (1.02 to 1.32)1.19 (1.05 to 1.34)
    Adjusted OR1.001.07 (0.93 to 1.23)1.07 (0.94 to 1.25)1.10 (0.96 to 1.25)
  • *Adjusted in the Bayesian hierarchical logistic regression model for deprivation, the presence or absence of a local registry and maternal age.

  • Values for special waste sites operational at some time between 1982 and 1997.