Table 1 Description of the 3005 working women of the PELAGIE cohort and risk factors for major malformations (chromosomal and genetic malformations excluded)
TotalTotalMajor malformationsNo malformations
No (%)No (%)No (%)
3005692897
Marital status
    Alone2946 (98.2)68 (98.6)2838 (98.1)
    Couple54 (1.8)1 (1.4)54 (1.9)
    Unknown5 (–)5 (–)
Geographical origin
    European2957 (98.8)68 (98.6)2849 (98.7)
    Other37 (1.2)1 (1.4)37 (1.3)
    Unknown11 (–)11 (–)
Parity
    01408 (46.9)41 (59.4)1351 (46.7)
    11123 (37.4)19 (27.5)1089 (37.7)
    2 and more469 (15.7)9 (13.1)452 (15.6)
    Unknown5 (–)5 (–)
Maternal age (years)
    <25311 (10.4)8 (11.6)298 (10.3)
    25–291230 (40.9)28 (40.6)1186 (40.9)
    30–341055 (35.1)26 (37.7)1018 (35.2)
    ≥35408 (13.6)7 (10.1)394 (13.6)
    Unknown1 (–)1 (–)
Education level
    Primary or secondary education496 (16.5)11 (15.9)478 (16.5)
    Baccalaureate551 (18.4)13 (18.8)523 (18.1)
    2 years or more higher education1954 (65.1)45 (65.3)1892 (65.4)
    Unknown4 (–)4 (–)
Tobacco consumption periconceptional and first trimester
    Non-smoker2131 (71.7)52 (75.4)2051 (71.6)
    At least one cigarette per day841 (28.3)17 (24.6)813 (28.4)
    Unknown33 (–)33 (–)
Alcohol consumption at inclusion
    0 drinks per week2524 (84.8)59 (85.5)2431 (84.7)
    At least one drink per week453 (15.2)10 (14.5)438 (15.3)
    Unknown28 (–)38 (–)
Diabetes mellitus
    No2833 (96.3)64 (95.5)2729 (96.2)
    Yes110 (3.7)3 (4.5)109 (3.8)
    Unknown62 (–)2 (–)59 (–)