Table 1 Description of studies, populations observed and effect estimates used in exposure-response estimate

Study	Population	Exposure assessment	Estimate (95% CI)
Hoek, 20022	Case-cohort of Dutch adults, n = 4492	Combination of interpolation from monitoring data, land use regression and estimated contribution of living next to major road based on other studies	NO₂ 1.36 (0.93 to 1.98) per 30 μg/m³
Hoek, 20022	Case-cohort of Dutch adults, n = 4492
Filleul, 200520	Cohort of French adults, n = 14 284	Measured at 18 centrally located monitoring stations	NO₂ 1.14 (1.03 to 1.25) per 10 μg/m³
Filleul, 200520	Cohort of French adults, n = 14 284	Measured at 18 centrally located monitoring stations
Gehring, 200621	Series of cross sectional studies among German adult females, n = 4752	5-Year average concentration measured at centrally located monitoring stations	NO₂ 1.19 (1.02 to 1.39) per 16 μg/m³PM₁₀ 1.13 (0.99 to 1.30) per 7 μg/m³
Krewski, 200019	Harvard Six Cities cohort of US adults, n = 8111	Measured at centrally located monitoring stations in six cities	NO₂1.25 (1.07 to 1.46) per 16 ppbPM₁₀ 1.28 (1.09 to 1.51) per 28 μg/m³*