Table 1 Major categories of environmentally responsive genes
Gene categoryFunctionExample
MetabolismControls biotransformation (including activation and detoxification) of endogenous and exogenous agents NAT2
DNA repairRepairs DNA damage caused by various endogenous and exogenous agents ERCC2/XPD
Cell cycle and cellRegulates cell proliferation, growth and differentiationCDK-2 (cell cycle)
Cell signallingEnables cellular communicatin by converting one kind of signal or stimulus into another STAT1
Major histocompatibility: class IICell-mediated immunity; transplanted tissue rejection; beryllium sensitisation HLA-DP1