MMVF exposure and lung cancer risk in Central/Eastern Europe and the UK
| Type of exposure | Exposure category | Central/Eastern Europe and the UK | |||
|---|---|---|---|---|---|
| Cases/controls | OR* | 95% CI | |||
| *Odds ratio adjusted for centre, age, tobacco smoking, silica, PAHs, asbestos, arsenic, chromium and cadmium. | |||||
| †Never exposed to any kind of synthetic fibres. | |||||
| ‡Excludes 12 subjects exposed to mixed synthetic fibres. | |||||
| MMVF (GF, MF) | Never† | 2078/2204 | 1.00 | ||
| Ever | 115/89 | 1.23 | 0.88 to 1.71 | ||
| Ceramic fibres only‡ | 7/5 | 1.25 | 0.33 to 4.74 | ||
| Exposure intensity to MMVF | Low | 73/61 | 1.23 | 0.82 to 1.84 | |
| Medium | 34/22 | 1.28 | 0.70 to 2.34 | ||
| High | 8/6 | 1.02 | 0.31 to 3.33 | ||
| Test for linear trend, p value | 0.87 | ||||
| Duration of MMVF exposure (years) | <2 | 7/2 | 3.81 | 0.59 to 24.52 | |
| 2–5 | 29/24 | 1.02 | 0.55 to 1.87 | ||
| 6–10 | 17/9 | 1.80 | 0.72 to 4.52 | ||
| 11–20 | 26/16 | 2.02 | 0.98 to 4.15 | ||
| 21–30 | 21/20 | 0.93 | 0.47 to 1.84 | ||
| 30+ | 15/18 | 0.77 | 0.35 to 1.68 | ||
| Test for linear trend, p value | 0.10 | ||||
| Cumulative MMVF exposure (fibres/ml*h) | <56.99 | 34/23 | 1.60 | 0.85 to 3.00 | |
| <180.99 | 25/25 | 0.97 | 0.52 to 1.80 | ||
| <839.97 | 27/23 | 1.17 | 0.63 to 2.19 | ||
| ⩾839.97 | 29/18 | 1.26 | 0.64 to 2.47 | ||
| Test for linear trend, p value | 0.62 | ||||
| Year of first MMVF exposure | –1960 | 45/31 | 1.36 | 0.80 to 2.31 | |
| 1961–70 | 30/29 | 1.09 | 0.60 to 1.97 | ||
| 1971–80 | 25/21 | 1.05 | 0.54 to 2.03 | ||
| 1981–90 | 11/6 | 1.64 | 0.54 to 4.96 | ||
| 1991– | 4/2 | 1.57 | 0.25 to 9.88 | ||
| Test for linear trend, p value | 0.72 | ||||