Asbestos exposure and lung cancer risk in Central and Eastern Europe and the UK respectively
| Type of exposure | Exposure category | Central and Eastern Europe | UK | ||
|---|---|---|---|---|---|
| Cases/controls | OR* (95% CI) | Cases/controls | OR* (95% CI) | ||
| *Odds ratio adjusted for centre, age, tobacco smoking, silica, PAHs, MMVF, arsenic, chromium and cadmium. | |||||
| †Excludes subjects exposed to unknown type of asbestos or combined exposure to amphiboles. | |||||
| Asbestos | Never | 1824/1908 | 1.00 (reference) | 64/95 | 1.00 (reference) |
| Ever | 233/246 | 0.92 (0.73 to 1.15) | 84/56 | 1.85 (1.07 to 3.21) | |
| Amphiboles | 58/63 | 0.93 (0.60 to 1.45) | 66/44 | 1.91 (1.06 to 3.45) | |
| Chrysotile | 99/120† | 0.77 (0.56 to 1.05) | 18/12 | 1.53 (0.61 to 3.86) | |
| Asbestos intensity | Low | 171/194 | 0.88 (0.68 to 1.13) | 49/33 | 2.01 (1.08 to 3.76) |
| Medium | 50/42 | 1.08 (0.67 to 1.73) | 22/15 | 1.66 (0.71 to 3.85) | |
| High | 12/10 | 0.95 (0.36 to 2.47) | 13/8 | 1.53 (0.51 to 4.54) | |
| Test for linear trend, p value | 0.46 | 0.62 | |||
| Cumulative asbestos exposure (fibres/ml*h) | <41.99 | 64/62 | 1.05 (0.70 to 1.59) | 18/14 | 1.66 (0.72 to 3.85) |
| <125.98 | 55/63 | 0.87 (0.57 to 1.31) | 19/15 | 2.03 (0.87 to 4.76) | |
| <699.95 | 49/68 | 0.70 (0.45 to 1.09) | 20/7 | 2.95 (1.05 to 8.26) | |
| ⩾699.95 | 65/53 | 1.07 (0.70 to 1.63) | 27/20 | 1.49 (0.67 to 3.33) | |
| Test for linear trend, p value | 0.60 | 0.95 | |||
| Year of first asbestos exposure | –1960 | 99/89 | 1.05 (0.74 to 1.50) | 57/41 | 1.77 (0.97 to 3.24) |
| 1961–70 | 74/86 | 0.90 (0.62 to 1.31) | 18/13 | 1.48 (0.56 to 3.91) | |
| 1971–80 | 36/45 | 0.72 (0.44 to 1.18) | 7/2 | 4.51 (0.72 to 28.24) | |
| 1981–90 | 16/19 | 0.70 (0.33 to 1.47) | 2/0 | ||
| 1991– | 8/7 | 1.47 (0.47 to 4.60) | 0/0 | ||
| Test for linear trend, p value | 0.35 | 0.20 | |||