Calculation of the number needed to screen for a low penetrant gene (GSTM1 and lung cancer) among workers exposed to PAH (from Vineis et al,2 modified)
| Measures | Estimates |
|---|---|
| Relative risk | 1.34 |
| Cumulative risk | 13% |
| Risk reduction | 50% |
| Cumulative risk after intervention | 6.5% |
| Absolute risk reduction | 6.5% |
| NNT | 15 |
| Allele frequency (null genotype) | 50% |
| NNS | 30 |