Genetic polymorphisms | Reference group | Studied groups | OR (95% CI) | p Value** |
CYP2D6 | *1*1 | *1*4 | 0.90 (0.75 to 1.07) | 0.16** |
*4*4 | 0.83 (0.55 to 1.26) | |||
PON1 L55M | M/M | L/M | 0.92 (0.77 to 1.09) | 0.31** |
L/L | 0.90 (0.69 to 1.18) | |||
PON1 Q192R | Q/Q | Q/R | 0.99 (0.83 to 1.17) | 0.67** |
R/R | 1.40 (0.83 to 1.57) | |||
GSTM1 | Positive | Null | 1.12 (0.95 to 1.31) | 0.18 |
GSTT1 | Positive | Null | 0.93 (0.75 to 1.56) | 0.52 |
GSTM3 | AA | AB | 1.01 (0.84 to 1.20) | 0.54** |
BB | 0.71 (0.42 to 1.22) | |||
GSTP1 haplotype | AA | AB/AC/AD | 0.98 (0.82 to 1.16) | 0.74 |
BB/BC/CC | 1.10 (0.83 to 1.47) | |||
NQO1 | *1*1 | *1*2 | 0.95 (0.80 to 1.13) | 0.41** |
*2*2 | 0.86 (0.55 to 1.34) | |||
CYP1B1 | *1*1 | *1*3 | 0.95 (0.79 to 1.13) | 0.76** |
*3*3 | 0.98 (0.77 to 1.24) | |||
MAO-A (males) | T | G | 1.30 (1.02 to 1.66) | 0.04 |
MAO-A (females) | TT | TG | 1.06 (0.82 to 1.36) | 0.55** |
GG | 1.26 (0.72 to 1.76) | |||
MAO-B (males) | A | G | 1.09 (0.87 to 1.36) | 0.45 |
MAO-B (females) | AA | AG | 1.14 (0.86 to 1.51) | 0.49** |
GG | 1.11 (0.79 to 1.56) | |||
SOD2 Val9Ala | AA | AV | 1.00 (0.82 to 1.22) | 0.95** |
VV | 0.99 (0.79 to 1.25) | |||
EPHX3 Y113H† | YY | YH | 0.89 (0.71 to 1.13) | 0.28** |
HH | 0.86 (0.61 to 1.21) | |||
EPHX4 H139R | HH | HR | 0.95 (0.80 to 1.13) | 0.72** |
RR | 1.37 (0.89 to 2.10) | |||
DAT1 | A/A | A/G | 0.94 (0.80 to 1.12) | 0.93** |
G/G | 1.13 (0.82 to 1.55) | |||
DRD2A††† | CC | CT | 0.93 (0.74 to 1.16) | 0.26** |
TT | 1.42 (1.00 to 2.03) | |||
DRD2B† | B2B2 | B2B1 | 0.95 (0.77 to 1.67) | 0.97** |
B1B1 | 1.27 (0.69 to 2.34) | |||
NAT2 | Fast/fast | Fast/slow | 1.04 (0.87 to 1.24) | 0.97** |
Slow/slow | 0.95 (0.71 to 1.26) |
*Logistic regression adjusting for age, sex, country, ever used tobacco containing product, ever knocked unconscious and first degree family history of Parkinson’s disease. MAO-A and MAO-B are not adjusted for sex but are presented for males and females separately.
**For three category factors p value for trend derived from logistic regression coding genetic factors as 0, 1 and 2 variable.
†Malta excluded from analysis involving DRD2B.
††Sweden and Italy excluded from analysis involving EPHX3.
†††Sweden and Malta excluded from analysis involving DRD2A.