Table 2 Analysis of genetic factors by case-control status (all cases versus controls) after adjustment*
Genetic polymorphismsReference groupStudied groupsOR (95% CI)p Value**
CYP2D6*1*1*1*40.90 (0.75 to 1.07)0.16**
*4*40.83 (0.55 to 1.26)
PON1 L55MM/ML/M0.92 (0.77 to 1.09)0.31**
L/L0.90 (0.69 to 1.18)
PON1 Q192RQ/QQ/R0.99 (0.83 to 1.17)0.67**
R/R1.40 (0.83 to 1.57)
GSTM1PositiveNull1.12 (0.95 to 1.31)0.18
GSTT1PositiveNull0.93 (0.75 to 1.56)0.52
GSTM3AAAB1.01 (0.84 to 1.20)0.54**
BB0.71 (0.42 to 1.22)
GSTP1 haplotypeAAAB/AC/AD0.98 (0.82 to 1.16)0.74
BB/BC/CC1.10 (0.83 to 1.47)
NQO1*1*1*1*20.95 (0.80 to 1.13)0.41**
*2*20.86 (0.55 to 1.34)
CYP1B1*1*1*1*30.95 (0.79 to 1.13)0.76**
*3*30.98 (0.77 to 1.24)
MAO-A (males)TG1.30 (1.02 to 1.66)0.04
MAO-A (females)TTTG1.06 (0.82 to 1.36)0.55**
GG1.26 (0.72 to 1.76)
MAO-B (males)AG1.09 (0.87 to 1.36)0.45
MAO-B (females)AAAG1.14 (0.86 to 1.51)0.49**
GG1.11 (0.79 to 1.56)
SOD2 Val9AlaAAAV1.00 (0.82 to 1.22)0.95**
VV0.99 (0.79 to 1.25)
EPHX3 Y113H†YYYH0.89 (0.71 to 1.13)0.28**
HH0.86 (0.61 to 1.21)
EPHX4 H139RHHHR0.95 (0.80 to 1.13)0.72**
RR1.37 (0.89 to 2.10)
DAT1A/AA/G0.94 (0.80 to 1.12)0.93**
G/G1.13 (0.82 to 1.55)
DRD2A†††CCCT0.93 (0.74 to 1.16)0.26**
TT1.42 (1.00 to 2.03)
DRD2B†B2B2B2B10.95 (0.77 to 1.67)0.97**
B1B11.27 (0.69 to 2.34)
NAT2Fast/fastFast/slow1.04 (0.87 to 1.24)0.97**
Slow/slow0.95 (0.71 to 1.26)
  • *Logistic regression adjusting for age, sex, country, ever used tobacco containing product, ever knocked unconscious and first degree family history of Parkinson’s disease. MAO-A and MAO-B are not adjusted for sex but are presented for males and females separately.

  • **For three category factors p value for trend derived from logistic regression coding genetic factors as 0, 1 and 2 variable.

  • †Malta excluded from analysis involving DRD2B.

  • ††Sweden and Italy excluded from analysis involving EPHX3.

  • †††Sweden and Malta excluded from analysis involving DRD2A.