Hazard ratio estimates of pancreatic cancer in relation to cumulative quantitative cotton dust and endotoxin exposures
| Exposure | Cases (n = 180) | Non-cases (n = 3183) | HR* | 95% CI | p for trend† |
|---|---|---|---|---|---|
| *Age (continuous) and smoking status (categories) adjusted hazard ratio. | |||||
| †Trend test for exposed women only. | |||||
| Cotton dust (mg/m3× years) | |||||
| No lag | |||||
| None | 54 | 1016 | 1.0 | Ref | |
| >0 to 55.9 | 30 | 542 | 1.1 | (0.7 to 1.7) | |
| >55.9 to 97.0 | 27 | 542 | 0.9 | (0.6 to 1.4) | |
| >97.0 to 143.4 | 36 | 540 | 1.0 | (0.6 to 1.6) | |
| >143.4 | 33 | 543 | 0.9 | (0.6 to 1.4) | 0.60 |
| 10 year lag | |||||
| None | 55 | 1026 | 1.0 | Ref | |
| >0 to 55.9 | 33 | 611 | 1.1 | (0.7 to 1.7) | |
| >55.9 to 97.0 | 30 | 520 | 1.0 | (0.6 to 1.6) | |
| >97.0 to 143.4 | 30 | 509 | 0.8 | (0.5 to 1.3) | |
| >143.4 | 32 | 517 | 0.9 | (0.6 to 1.4) | 0.34 |
| 20 year lag | |||||
| None | 61 | 1198 | 1.0 | Ref | |
| >0 to 55.9 | 41 | 637 | 1.2 | (0.8 to 1.8) | |
| >55.9 to 97.0 | 31 | 455 | 1.0 | (0.6 to 1.5) | |
| >97.0 to 143.4 | 27 | 457 | 0.7 | (0.5 to 1.2) | |
| >143.4 | 20 | 436 | 0.6 | (0.3 to 0.9) | 0.006 |
| Endotoxin (EU/m3× years) | |||||
| No lag | |||||
| None | 54 | 916 | 1.0 | Ref | |
| >0 to 1517.4 | 32 | 530 | 1.0 | (0.7 to 1.6) | |
| >1517.4 to 2430.0 | 36 | 529 | 1.1 | (0.7 to 1.6) | |
| >2430.0 to 3530.6 | 24 | 530 | 0.6 | (0.4 to 1.1) | |
| >3530.6 | 30 | 529 | 0.8 | (0.5 to 1.2) | 0.12 |
| 10 year lag | |||||
| None | 55 | 926 | 1.0 | Ref | |
| >0 to 1517.4 | 36 | 627 | 1.1 | (0.7 to 1.7) | |
| >1517.4 to 2430.0 | 35 | 501 | 1.0 | (0.7 to 1.6) | |
| >2430.0 to 3530.6 | 23 | 479 | 0.6 | (0.4 to 1.1) | |
| >3530.6 | 27 | 501 | 0.7 | (0.4 to 1.1) | 0.04 |
| 20 year lag | |||||
| None | 61 | 1093 | 1.0 | Ref | |
| >0 to 1517.4 | 46 | 663 | 1.2 | (0.8 to 1.8) | |
| >1517.4 to 2430.0 | 35 | 462 | 1.0 | (0.6 to 1.5) | |
| >2430.0 to 3530.6 | 15 | 402 | 0.4 | (0.2 to 0.8) | |
| >3530.6 | 19 | 414 | 0.5 | (0.3 to 0.9) | <0.001 |