Correlation of renal toxicity markers with magnitude and duration of exposure to trichloroethylene
| Parameter I/group | Parameter II, mean | Correlation coefficient | R2 | Significance (p) |
|---|---|---|---|---|
| Trichloroacetic acid (TCA) was used as a biomarker of exposure. Figures in parentheses represents number of individuals per group. | ||||
| *n = 69. Years of exposure was not available for one individual | ||||
| TCA | GST-α | |||
| <18 (19) | 5.66 | |||
| 18–43 (17) | 5.69 | |||
| 43–103 (17) | 10.12 | |||
| 103–386 (17) | 11.82 | 0.439 | 0.192 | <0.01† |
| Years* | GST-α | |||
| 0–1 (15) | 8.62 | |||
| 1–4 (24) | 8.50 | |||
| 4–7 (17) | 6.91 | |||
| 7–20 (13) | 7.72 | 0.177 | 0.031 | NS (0.145) |
| TCA | NAG | |||
| <18 (19) | 6.45 | |||
| 18–43 (17) | 4.81 | |||
| 43–103 (17) | 4.51 | |||
| 103–386 (17) | 5.17 | 0.088 | 0.007 | NS (0.47) |
| Years* | NAG | |||
| 0–1 (15) | 3.74 | |||
| 1–4 (24) | 5.80 | |||
| 4–7 (17) | 6.32 | |||
| 7–20 (13) | 5.00 | 0.045 | 0.002 | NS (0.71) |
| TCA | U ALB | |||
| <18 (19) | 8.62 | |||
| 18–43 (17) | 14.19 | |||
| 43–103 (17) | 8.16 | |||
| 103–386 (17) | 7.99 | 0.104 | 0.011 | NS (0.39) |
| RBP vs age | – | 0.361 | 0.130 | <0.01† |