Conditions specified for simulation
| Parameter | Value |
|---|---|
| †δ0 and δ1 are parameters for a Weibull model, centred at age 55 years, describing the annual rate of mortality in the absence of exposure; values for δ0 and δ1 are specified such that simulations approximate the age specific cancer mortality rates in a large cohort of US workers. | |
| ‡η0 and η1 are parameters for a Weibull model, centred at age 55 years, describing the rate of mortality due to causes other than the one under study. | |
| The exponential distribution, with mean and variance equal to 1, is denoted Exp(1). | |
| Number of iterations of simulation | 100 |
| Number of persons in study cohort | 25000 |
| Age at entry, in years | 18+10(Exp(1)) |
| Length of follow up, in years | 40-5(Exp(1)) |
| Length of employment, in years | 25Exp(1) |
| Baseline disease incidence rate, (δ0, δ1)† | −6.3, 5.7 |
| Rate of censoring due to death from causes other than the one under study, (η0, η1)‡ | −5.0, 5.0 |
| Exposure effect (per 10 units exposure), eφ | 1.50 |