Table 1

Conditions specified for simulation

ParameterValue
δ0 and δ1 are parameters for a Weibull model, centred at age 55 years, describing the annual rate of mortality in the absence of exposure; values for δ0 and δ1 are specified such that simulations approximate the age specific cancer mortality rates in a large cohort of US workers.
η0 and η1 are parameters for a Weibull model, centred at age 55 years, describing the rate of mortality due to causes other than the one under study.
The exponential distribution, with mean and variance equal to 1, is denoted Exp(1).
Number of iterations of simulation100
Number of persons in study cohort25000
Age at entry, in years18+10(Exp(1))
Length of follow up, in years40-5(Exp(1))
Length of employment, in years25Exp(1)
Baseline disease incidence rate, (δ0, δ1)†−6.3, 5.7
Rate of censoring due to death from causes other than the one under study, (η0, η1)‡−5.0, 5.0
Exposure effect (per 10 units exposure), eφ1.50