Relations between symptoms and specific sensitisation and three exposure indices in laboratory animal workers
| Any symptoms | Chest symptoms | Eye/nose symptoms | Skin symptoms | Skin prick test | SORA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exposure categories | RR | 95% CI | RR | 95% CI | RR | 95% CI | RR | 95% CI | RR | 95% CI | RR | 95% CI |
| The estimates are adjusted for smoking and atopic status (see text for rate ratios). | ||||||||||||
| RUA intensity of exposure (μg/m3) | ||||||||||||
| 1 – Low | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| 2 | 1.6 | 0.8 to 3.1 | 3.1 | 0.6 to 14.9 | 1.2 | 0.6 to 2.6 | 2.6 | 0.7 to 10.2 | 3.7 | 1.0 to 13.3 | 2.7 | 0.3 to 26.9 |
| 3 | 1.9 | 1.0 to 3.6 | 4.9 | 1.1 to 21.9 | 1.6 | 0.8 to 3.2 | 3.2 | 0.9 to 11.6 | 4.3 | 1.2 to 14.7 | 5.4 | 0.7 to 43.5 |
| 4 – High | 1.9 | 1.0 to 3.5 | 4.1 | 0.9 to 18.9 | 1.0 | 0.5 to 2.2 | 5.0 | 1.4 to 17.3 | 4.9 | 1.4 to 17.2 | 2.8 | 0.3 to 25.8 |
| Hours/week exposure (h/wk) | ||||||||||||
| Not working with rats | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Not working with conscious rats | 1.4 | 0.8 to 2.6 | 0.9 | 0.3 to 2.8 | 2.8 | 1.1 to 6.9 | 7.9 | 1.0 to 63.2 | 0.4 | 0.1 to 1.6 | 0.3 | 0.0 to 2.6 |
| Working with conscious rats | ||||||||||||
| 0–10 | 1.0 | 0.5 to 2.0 | 1.8 | 0.6 to 5.2 | 3.3 | 1.2 to 8.8 | 11.4 | 1.4 to 92.9 | 3.0 | 1.2 to 7.6 | 2.5 | 0.6 to 10.3 |
| 10–30 | 1.4 | 0.7 to 2.8 | 0.8 | 0.2 to 3.0 | 2.5 | 0.9 to 6.7 | 17.0 | 2.2 to 132.9 | 2.3 | 0.9 to 6.1 | 1.4 | 0.3 to 7.2 |
| ≥30 | 1.8 | 0.9 to 3.6 | 2.3 | 0.7 to 7.0 | 3.9 | 1.4 to 10.6 | 21.7 | 2.6 to 177.2 | 3.6 | 1.3 to 9.8 | 1.7 | 0.3 to 8.8 |
| RUA level * hours/week exposure (μg/m3.h/wk) | ||||||||||||
| Not working with rats | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Not working with conscious rats | 1.4 | 0.8 to 2.5 | 0.9 | 0.3 to 2.8 | 2.8 | 1.1 to 6.9 | 7.9 | 1.0 to 63.2 | 0.4 | 0.1 to 1.6 | 0.3 | 0.0 to 2.6 |
| Working with conscious rats | ||||||||||||
| 0–150 | 1.2 | 0.6 to 2.5 | 1.8 | 0.6 to 5.5 | 3.3 | 1.2 to 9.0 | 11.9 | 1.4 to 99.0 | 3.2 | 1.3 to 8.1 | 2.5 | 0.6 to 10.4 |
| 150–900 | 1.0 | 0.5 to 2.1 | 0.9 | 0.2 to 3.2 | 2.6 | 0.9 to 7.0 | 16.6 | 2.1 to 131.1 | 1.9 | 0.7 to 5.5 | 1.5 | 0.3 to 7.8 |
| ≥900 | 1.8 | 0.9 to 3.4 | 1.9 | 0.7 to 5.9 | 3.7 | 1.4 to 9.6 | 18.8 | 2.4 to 149.8 | 3.4 | 1.4 to 9.0 | 1.7 | 0.4 to 8.1 |