Table 4

Multiple regression of annual lung function change over two years on laboratory animal sensitisation, recent exposure, and the presence of respiratory symptoms in subjects working with laboratory animals for less than four years (n=102)

ParameternΔFEV1 (ml/y) β (SE)ΔFVC (ml/y) β (SE)ΔMMEF (ml/s/y) β (SE)
*p<0.05; **p<0.01.
Gender (female)5644.7 (19.4)*14.5 (22.1)83.7 (40.7)*
Age (/10 y)−16.4 (15.3)−9.8 (17.4)−22.1 (32.0)
Pack-years (/y)0.5 (2.5)1.9 (2.8)0.0 (5.2)
Former smoker1530.8 (28.4)1.3 (32.3)7.7 (59.5)
Common atopy45−10.2 (20.9)10.6 (23.9)−65.3 (43.9)
Recently exposed to laboratory animals82−41.1 (25.0)24.0 (28.5)−105.9 (52.4)*
Sensitised to laboratory animals2611.6 (30.4)−28.6 (34.6)−34.7 (63.7)
Sensitised and exposed to the same laboratory animal13−91.1 (39.7)*−119.4 (45.2)**28.4 (83.2)
Symptoms of respiratory allergy to laboratory animals15−22.0 (28.6)−37.7 (32.6)30.4 (60.0)