Table 3

Univariate regression analysis of annual lung function change over two years in laboratory animal workers on subject characteristics in subjects working with laboratory animals for more than four years (n=217)

ParameternΔFEV1 (ml/y) β (SE)ΔFVC (ml/y) β (SE)ΔMMEF (ml/s/y) β (SE)
*p<0.05; **p<0.01.
Gender (female)6036.5 (14.3)*39.6 (17.4)*10.1 (35.5)
Age (/10 y)−14.2 (7.4)−25.7 (8.9)**−4.1 (18.2)
Standing height (/10 cm)−10.7 (7.4)−9.9 (9.0)−9.6 (18.1)
Body weight (/10 kg)−14.8 (5.5)**−20.8 (6.6)**−7.8 (13.7)
Current smoker51−6.5 (15.3)−5.0 (18.6)−34.8 (37.4)
Former smoker78−4.2 (13.6)−11.9 (16.4)6.4 (33.1)
Pack-years (/y)−2.2 (0.7)**−2.1 (0.9)*−2.5 (1.8)
Common atopy990.5 (13.1)1.5 (15.8)−11.2 (31.9)
Chronic respiratory symptoms567.3 (14.9)7.8 (18.0)32.5 (36.2)
Bronchitis symptoms18−2.7 (23.6)31.5 (28.5)−62.9 (57.4)
Asthma symptoms473.4 (15.8)11.7 (19.1)16.4 (38.6)
History of non-occupational allergy6015.6 (14.5)31.5 (17.5)5.5 (35.5)
Airway hyperreactivity285.3 (19.5)12.2 (23.6)20.3 (47.4)
Years worked with laboratory animals (/y)−1.3 (0.7)−1.8 (0.9)*−1.5 (1.7)
Recently exposed to laboratory animals203−34.0 (26.4)−24.4 (32.0)−26.5 (64.6)
Sensitised to laboratory animals62−11.2 (14.4)−6.1 (17.4)−42.7 (35.1)
Symptoms of respiratory allergy to laboratory animals3332.6 (18.0)61.1 (21.6)**0.5 (44.2)