Univariate regression analysis of annual lung function change over two years in laboratory animal workers on subject characteristics in subjects working with laboratory animals for less than four years (n=102)
| Parameter | n | ΔFEV1 (m/y) β (SE) | ΔFVC (ml/y) β (SE) | ΔMMEF (ml/s/y) β (SE) |
|---|---|---|---|---|
| *p<0.05; **p<0.01. | ||||
| Gender (female) | 56 | 57.9 (19.4)** | 41.1 (22.8) | 85.6 (38.7)* |
| Age (/10 y) | −12.5 (14.4) | −9.5 (16.5) | −21.2 (28.3) | |
| Standing height (/10 cm) | −20.9 (9.9)* | −18.3 (11.4) | −25.2 (19.6) | |
| Body weight (/10 kg) | −12.1 (8.3) | −14.8 (9.5) | −30.1 (16.2) | |
| Current smoker | 20 | −3.4 (25.3) | −13.1 (28.9) | 40.4 (49.5) |
| Former smoker | 15 | 1.5 (28.4) | −26.5 (32.4) | −5.6 (55.6) |
| Pack-years (/y) | 1.0 (2.5) | 2.3 (2.9) | −0.6 (4.9) | |
| Common atopy | 45 | −36.2 (19.9) | −35.5 (22.9) | −81.7 (38.9)* |
| Chronic respiratory symptoms | 25 | −41.4 (23.0) | −4.6 (26.7) | −73.3 (45.2) |
| Bronchitis symptoms | 4 | −80.7 (51.2) | −23.4 (59.2) | −101.2 (101.0) |
| Asthma symptoms | 23 | −31.2 (23.9) | 2.6 (27.5) | −66.5 (46.7) |
| History of non-occupational allergy | 23 | −43.2 (23.7) | −27.7 (27.4) | −72.5 (46.6) |
| Airway hyperreactivity | 17 | −31.1 (26.8) | −26.1 (30.8) | −28.9 (52.8) |
| Years worked with laboratory animals (/y) | −12.0 (9.2) | −0.9 (10.6) | −38.1 (17.8)* | |
| Recently exposed to laboratory animals | 82 | −48.6 (24.9) | 4.9 (29.0) | −76.4 (49.1) |
| Sensitised to laboratory animals | 26 | −48.4 (22.6)* | −95.4 (24.6)** | −56.1 (44.9) |
| Symptoms of respiratory allergy to laboratory animals | 15 | −67.0 (27.6)* | −86.9 (31.3)** | −24.2 (55.6) |