Summary of data, methods, and lung cancer unit risk estimates for lifetime exposure to 1 μg/m3 of crystalline silica derived from risk analyses of toxicological or epidemiological data
| Reference | Data source | Exposure metric | Statistical model | Risk estimate | |
| Collins and Marty19 | Geometric mean of risk estimates from rat inhalation studies24-26 | Respirable silica (quartz) particles | Linearised multistage (GLOBAL 86) | 2.9 × 10−4 (95% upper confidence limit) (with surface area correction factor) | |
| Goldsmith et al 18 | Mortality study of diatomaceous earth workers4 | Cumulative exposure to respirable silica (exposure intensity × years) (mainly cristobalite) with 15 year lag | Linearised multistage (GLOBAL 86) | 1.83 × 10−7 | |
| Cohort mortality study of South African gold miners21 | Gold mining dust containing quartz | Linearised multistage (GLOBAL 86) | 6.75 × 10−5 | ||
| Goldsmith et al 18 | Risk estimates from rat inhalation studies24-26 | Respirable silica (quartz) particles | Linearised multistage (GLOBAL 86) | 6 × 10−3 (95% upper confidence limit) (highest of 5 estimates) (with surface area correction factor) | |
| Riceet al (this study) | Mortality study of diatomaceous earth workers2 | Cumulative exposure to respirable silica with 10 year lag (mainly cristobalite) in mg/m3.years | Poisson regression: linear relative rate | 3.8 × 10−4 (white men) | |