Table 3

Description of published substance specific studies which examined workers in the mortality surveillance study

Purpose of study, definition of study group, and reference Workers under Surveillance Disease site(s) of interest (ICD-8)3-150 Author(s)
finding of cause
Study result SMR (95% CI) [obs] Surveillance results (⩾20 y induction-latency) SMR (95% CI) [obs or exp]
261 Workers employed at the Nitro plant with potential exposure to 4-aminobiphenyl15 52Bladder cancer (188,189.9)Yes42/261 Workers developed bladder cancer1.6 (0.0 to 8.8) [1]
54 Workers employed at the Queeny plant with potential exposure to 4-aminobiphenyl15 11Bladder cancer (188,189.9)Yes10/54 Workers developed bladder cancer1.9 (0.2 to 7.0) [2]
2490 Male hourly workers at the Indian Orchard plant working 1 year between 1949–66 with follow up to the end of 197619 224Genitourinary tract cancers (185–189)Yes1.7 (1.1 to 2.5) [26]0.3 (0.0 to 0.8) [4]
Cancer of digestive organs and peritoneum (150–159)Yes1.3 (0.9 to 1.7) [44]1.2 (0.8 to 1.8) [26]
2731 Workers employed at the Indian Orchard plant with potential exposure to formaldehyde22 218Lung cancer (162)No1.1 (1.0 to 1.3) For all plants in study0.6 (0.4 to 0.9) [23]
452 Workers with exposure to dioxins from 1948–69 at the Nitro plant24 36Lung cancer (162)Yes1.4 (0.8 to 0.4) [15]0.6 (0.2 to 1.3) [6]
Soft tissue sarcoma (171)Yes15.2 (1.9 to 55.6) [2]0.0 (0.0 to 121.0) [0.16 exp]
96 Workers with exposure to dioxins from 1948–69 at the Krummrich plant24 7Lung cancer (162)Yes2.4 (0.5 to 7.0) [3]0.9 (0.5 to 1.4) [18]
Soft tissue sarcoma (171)Yes0.0 [0]0.0 (0.0 to 14.9)
754 Workers employed at the Nitro plant during 1949 with follow up to the end of 198727 128Soft tissue sarcoma (171,173.9)Yes6.7 (1.4 to 19.4) [3]0.0 (0.0 to 121.0) [0.16 exp]
Bladder cancer (188,189.9)Yes6.8 (3.9 to 11.1) [16]1.6 (0.0 to 8.8) [1]
666 Production workers at the Krummrich plant 1940–77 with follow up to the end of 199129 406Leukaemia (204–207)Yes1.4 (0.8 to 2.2) [19]2.4 (0.7 to 6.2) [4]
Multiple myeloma (203)Yes1.3 (0.5 to 2.5) [8]1.2 (0.0 to 6.8) [1]
2039 Workers employed at the Chocolate Bayou plant 1962–1983 with follow up to the end of 198930 1468Lung cancer (162)No0.2 (0.0 to 1.1) [1]0.5 (0.1 to 1.3) [4]
Brain cancer (191,192)No1.2 (0.2 to 8.3) [1]1.8 (0.0 to 9.9) [1]
Prostate cancer (185)No2.1 (0.3 to 14.9) [1]0.0 (0.0 to 4.2) [0.86 exp]
7372 Workers employed at the Decatur plant 1952–83 with follow up to the end of 198930 5308Lung cancer (162)No0.6 (0.4 to 0.9) [2]0.6 (0.3 to 1.0) [13]
Brain cancer (191,192)No0.8 (0.3 to 2.1) [4]1.8 (0.0 to 9.9) [1]
Prostate cancer (185)No0.9 (0.3 to 2.5) [4]1.0 (0.2 to 3.0) [3]
2368 Workers employed at the Port Plastics plant 1959–83 with follow up to the end of 198930 1705Lung cancer (162)No0.8 (0.4 to 1.5) [8]0.9 (0.4 to 1.8) [7]
Brain cancer (191,192)No0.0 (0.0 to 2.7) [0]1.5 (0.0 to 8.3) [1]
Prostate cancer (185)No0.0 (0.0 to 4.0) [0]1.1 (0.0 to 5.9) [1]
600 White male hourly 2-mercaptobenzothizole workers at the Nitro plant working between 1955–77 with follow up to the end of 197631 390Bladder cancer (188,189.9)Yes6.3 (3.6 to 10.3) [16]1.6 (0.0 to 8.8) [1]
185 Workers employed at the Indian Orchard plant with potential exposure to vinyl chloride32 98Liver cancer (155,156)Yes3.5 (2.8 to 4.5) For all plants in study:
 1 death at plant
0.0 (0.0 to 1.6) [2.33 exp]
Brain cancer (191–192)Possibly1.4 (1.0 to 2.0) For all plants in study:
 no deaths at plant
0.4 (0.0 to 2.3) [1]
Soft tissue sarcoma (171)Yes2.7 (1.4 to 4.7) For all plants in study:
 no deaths at plant
0.0 (0.0 to 7.6) [0.48 exp]
  • 3-150 Hypothesis tested in study or high rate of disease reported.