Table 3

Estimated effects (obtained from a multivariate logistic regression; OR (95% CI)) of exposure to sprayed (dichotomised into yes and no) or heated (dichotomised into yes and no) polyurethane glue in 152 workers on concentrations of metabolites, antibodies, work related symptoms, and lung function measurements

Sprayed glue
OR (95% CI)
Heated glue
OR (95% CI)
Metabolites3-150:
 P-MDX3-151 0.72 (0.26 to 2.0)12 (4.4 to 30)
 U-MDX3-152 2.2 (0.7 to 77)2.2 (0.5 to 8.9)
 P-2,4-TDX3-152 6.2 (1.8 to 22)1.1 (0.30 to 4.1)
 U-2,4-TDX3-152 1.3 (0.60 to 3.1)0.70 (0.30 to 1.6)
 P-2,6-TDX3-152 16 (1.4 to 180)1.9 (0.20 to 23)
 U-2,6-TDX3-152 2.3 (0.30 to 15)1.5 (0.20 to 12)
Antibodies3-150:
 S-IgG-MDI3-153 1.1 (0.45 to 2.6)3.7 (1.4 to 9.5)3-154
 S-IgG-TDI3-153 1.5 (0.64 to 3.6)1.5 (0.59 to 3.6)3-154
 S-IgG-HDI3-153 3.6 (0.92 to 14)3-154 1.7 (0.36 to 8.2)3-154
 S-IgE-MDI3-153
 S-IgG3-151 2.4 (1.0 to 5.8)0.97 (0.43 to 2.1)
 S-IgM3-151 1.5 (0.65 to 3.5)1.3 (0.56 to 3.1)3-154
 S-IgA3-151 1.3 (0.57 to 3.1)0.62 (0.28 to 1.4)
 S-IgE3-151 0.55 (0.24 to 1.3)1.5 (0.67 to 3.3)
Work related symptoms:
 Total3.0 (1.2 to 7.4)1.2 (0.49 to 2.9)
  Eyes1.2 (0.37 to 3.8)0.85 (0.27 to 2.7)
  Airways1.9 (0.77 to 4.7)1.6 (0.63 to 3.9)
   Nose1.7 (0.64 to 4.7)1.2 (0.43 to 3.1)
   Lower1.3 (0.39 to 4.4)2.2 (0.61 to 8.1)
Lung function3-150:
 VC3-151 3.0 (1.3 to 7.3)0.49 (0.22 to 1.1)
 FEV1 3-151 4.2 (1.6 to 11)0.29 (0.12 to 0.70)
  • 3-150 P-MDX and U-MDX=metabolites of 4,4′-diphenylmethane diisocyanate (MDI), P-2,4-TDX and U-2,4-TDX and P-2,6- TDX and U-2,6-TDX=metabolites of 2,4-toluene diisocyanate and 2,6-toluene diisocyanate (TDI) in plasma and urine; S-IgG-MDI, S-IgG-TDI, S-IgG-HDI, and S-IgE-MDI=specific serum antibodies against MDI, TDI, and hexamethylene diisocyanate; S-IgG, S-IgM, S-IgA, S-IgE=total serum IgG, IgM, IgA, and IgE antibodies; VC=vital capacity, FEV1=forced exspiratory volume in 1 second.

  • 3-151 Dichotomised at median value.

  • 3-152 Dichotomised at the limit of measurement.

  • 3-153 Dichotomised into positive and negative values.

  • 3-154 Adjusted for age and sex.