Estimated annual change in FVC and FEV1 in selected subgroups of the population based on generalised estimating equation (GEE) analysis approach
| Population subgroup | n | PFTs n | FVC | FEV1 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (l) | Slope estimate (95% CI) (l/y) | Baseline (l) | Slope estimate (95% CI) (l/y) | ||||||||
| Total group | 296 | 2641 | 4.68 | −0.035 (−0.031 to −0.039) | 3.76 | −0.036 (−0.033 to −0.039) | |||||
| Women | 22 | 169 | 3.58 | −0.0196-150 (−0.011 to −0.026) | 2.97 | −0.023 (−0.017 to −0.029) | |||||
| Exposed | 10 | 88 | 3.62 | −0.0206-150 (−0.016 to −0.024) | 3.07 | −0.027 (−0.022 to −0.032) | |||||
| Referents | 12 | 81 | 3.55 | −0.014 ( 0.004 to −0.033) | 2.89 | −0.014 (−0.006 to −0.022) | |||||
| Men | 274 | 2472 | 4.77 | −0.036 (−0.032 to −0.040) | 3.82 | −0.037 (−0.033 to −0.040) | |||||
| Exposed | 209 | 1866 | 4.83 | −0.037 (−0.033 to −0.042) | 3.87 | −0.037 (−0.033 to −0.041) | |||||
| Referents | 65 | 606 | 4.59 | −0.034 (−0.027 to −0.041) | 3.67 | −0.035 (−0.028 to −0.042) | |||||
| Men, never smokers | 92 | 862 | 4.76 | −0.033 (−0.026 to −0.041) | 3.85 | −0.033 (−0.027 to −0.039) | |||||
| Exposed | 67 | 620 | 4.82 | −0.0336-150 (−0.024 to −0.041) | 3.89 | −0.0316-150 (−0.024 to −0.039) | |||||
| Referents | 25 | 242 | 4.62 | −0.0346-150 (−0.022 to −0.047) | 3.74 | −0.0366-150 (−0.028 to −0.043) | |||||
| Men (⩾20 cigarette pack-years) | 96 | 855 | 4.60 | −0.043 (−0.037 to −0.049) | 3.59 | −0.044 (−0.039 to −0.049) | |||||
| Exposed | 72 | 637 | 4.70 | −0.044 (−0.036 to −0.053) | 3.70 | −0.043 (−0.038 to −0.049) | |||||
| Referents | 24 | 218 | 4.29 | −0.041 (−0.031 to −0.051) | 3.28 | −0.044 (−0.034 to −0.055) | |||||
| Men with non-occupational asthma | 19 | 184 | 4.58 | −0.028 (−0.011 to −0.046) | 3.49 | −0.0316-150 (−0.017 to −0.044) | |||||
| Men with occupational asthma | 15 | 142 | 4.70 | −0.037 (−0.026 to −0.049) | 3.58 | −0.034 (−0.023 to −0.045) | |||||
↵6-150 Non-convergence of GEE estimates after 50 iterations.