RT Journal Article
SR Electronic
T1 Testicular germ cell tumour risk by occupation and industry: a French case–control study – TESTIS
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP oemed-2022-108601
DO 10.1136/oemed-2022-108601
A1 Margot Guth
A1 Astrid Coste
A1 Marie Lefevre
A1 Floriane Deygas
A1 Aurélie Danjou
A1 Shukrullah Ahmadi
A1 Brigitte Dananché
A1 Olivia Pérol
A1 Helen Boyle
A1 Joachim Schüz
A1 Louis Bujan
A1 Catherine Metzler-Guillemain
A1 Sandrine Giscard d’Estaing
A1 Marius Teletin
A1 Berengere Ducrocq
A1 Cynthia Frapsauce
A1 Ann Olsson
A1 Barbara Charbotel
A1 Béatrice Fervers
A1 ,
YR 2023
UL http://oem.bmj.com/content/early/2023/05/24/oemed-2022-108601.abstract
AB Objective Testicular germ cell tumours (TGCT) are the most common cancer in men of working age and its incidence has increased notably over the past 40 years. Several occupations have been identified as potentially associated with TGCT risk. The aim of this study was to further explore the relationship between occupations, industries and TGCT risk in men aged 18–45 years.Methods The TESTIS study is a multicenter case–control study conducted between January 2015 and April 2018 in 20 of 23 university hospital centers in metropolitan France. A total of 454 TGCT cases and 670 controls were included. Full job histories were collected. Occupations were coded according to the International Standard Classification of Occupation 1968 version (ISCO-1968) and industry according to the 1999 version of Nomenclature d’Activités Française (NAF-1999). For each job held, ORs and 95% CIs were estimated using conditional logistic regression.Results A positive association was observed between TGCT and occupation as agricultural, animal husbandry worker (ISCO: 6–2; OR 1.71; 95% CI (1.02 to 2.82)), as well as salesman (ISCO: 4–51; OR 1.84; 95% CI (1.20 to 2.82)). An increased risk was further observed among electrical fitters and related, electrical and electronics workers employed for 2 years or more (ISCO: 8–5; OR≥2 years 1.83; 95% CI (1.01 to 3.32)). Analyses by industry supported these findings.Conclusions Our findings suggest that agricultural, electrical and electronics workers, and salesmen workers experience an increased risk of TGCT. Further research is needed to identify the agents or chemicals in these high-risk occupations which are relevant in the TGCT development.Trial registration number NCT02109926.Data are available on reasonable request. The data collection process is described in the Method section of this article.