TY - JOUR T1 - Herbicide use in farming and other jobs in relation to non-Hodgkin’s lymphoma (NHL) risk JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 795 LP - 806 DO - 10.1136/oemed-2022-108371 VL - 79 IS - 12 AU - Anneclaire J De Roos AU - Lin Fritschi AU - Mary H Ward AU - Alain Monnereau AU - Jonathan Hofmann AU - Leslie Bernstein AU - Parveen Bhatti AU - Yolanda Benavente Moreno AU - Geza Benke AU - Delphine Casabonne AU - Jacqueline Clavel AU - Pierluigi Cocco AU - Tran Huynh AU - Andrea 't Mannetje AU - Lucia Miligi AU - Sara Piro AU - Nathaniel Rothman AU - Leah H Schinasi AU - Claire M Vajdic AU - Sophia S Wang AU - Yawei Zhang AU - Susan L Slager AU - James R Cerhan Y1 - 2022/12/01 UR - http://oem.bmj.com/content/79/12/795.abstract N2 - Objectives Given mixed evidence for carcinogenicity of current-use herbicides, we studied the relationship between occupational herbicide use and risk of non-Hodgkin’s lymphoma (NHL) in a large, pooled study.Methods We pooled data from 10 case-control studies participating in the International Lymphoma Epidemiology Consortium, including 9229 cases and 9626 controls from North America, the European Union and Australia. Herbicide use was coded from self-report or by expert assessment in the individual studies, for herbicide groups (eg, phenoxy herbicides) and active ingredients (eg, 2,4-dichlorophenoxyacetic acid (2,4-D), glyphosate). The association between each herbicide and NHL risk was estimated using logistic regression to produce ORs and 95% CIs, with adjustment for sociodemographic factors, farming and other pesticides.Results We found no substantial association of all NHL risk with ever-use of any herbicide (OR=1.10, 95% CI: 0.94 to 1.29), nor with herbicide groups or active ingredients. Elevations in risk were observed for NHL subtypes with longer duration of phenoxy herbicide use, such as for any phenoxy herbicide with multiple myeloma (>25.5 years, OR=1.78, 95% CI: 0.74 to 4.27), 2,4-D with diffuse large B-cell lymphoma (>25.5 years, OR=1.47, 95% CI: 0.67 to 3.21) and other (non-2,4-D) phenoxy herbicides with T-cell lymphoma (>6 years, lagged 10 years, OR=3.24, 95% CI: 1.03 to 10.2). An association between glyphosate and follicular lymphoma (lagged 10 years: OR=1.48, 95% CI: 0.98 to 2.25) was fairly consistent across analyses.Conclusions Most of the herbicides examined were not associated with NHL risk. However, associations of phenoxy herbicides and glyphosate with particular NHL subtypes underscore the importance of estimating subtype-specific risks. ER -