RT Journal Article
SR Electronic
T1 Lung cancer risk in relation to jobs held in a nationwide case–control study in Iran
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 831
OP 838
DO 10.1136/oemed-2022-108463
VO 79
IS 12
A1 Bayan Hosseini
A1 Ann Olsson
A1 Liacine Bouaoun
A1 Amy Hall
A1 Maryam Hadji
A1 Hamideh Rashidian
A1 Ahmad Naghibzadeh-Tahami
A1 Maryam Marzban
A1 Farid Najafi
A1 Ali Akbar Haghdoost
A1 Paolo Boffetta
A1 Farin Kamangar
A1 Eero Pukkala
A1 Arash Etemadi
A1 Elisabete Weiderpass
A1 Joachim Schüz
A1 Kazem Zendehdel
YR 2022
UL http://oem.bmj.com/content/79/12/831.abstract
AB Background Globally, lung cancer is the most frequent occupational cancer, but the risk associated with the occupations or occupational environment in Iran is not clear. We aimed to assess occupations with the risk of lung cancer.Methods We used the IROPICAN nationwide case–control study data including 658 incident lung cancer cases and 3477 controls. We assessed the risk of lung cancer in relation to ever working in major groups of International Standard Classification of Occupations, high-risk occupations for lung cancer and duration of employment and lung cancer subtype among construction workers and farmers while controlling for cigarette smoking and opium consumption. We used unconditional regression logistic models to estimate ORs for the association between increased lung cancer risk and occupations.Results We observed elevated ORs for lung cancer in male construction workers (OR=1.4; 95% CI: 1.0 to 1.8), petroleum industry workers (OR=3.2; 95% CI: 1.1 to 9.8), female farmers (OR=2.6; 95% CI: 1.3 to 5.3) and female bakers (OR=5.5; 95% CI: 1.0 to 29.8). A positive trend by the duration of employment was observed for male construction workers (p< 0.001). Increased risk of squamous cell carcinoma was observed in male construction workers (OR=1.9; 95% CI: 1.2 to 3.0) and female farmers (OR=4.3; 95% CI: 1.1 to 17.2), who also experienced an increased risk of adenocarcinoma (OR=3.8; 95% CI: 1.4 to 9.9).Discussion Although we observed associations between some occupations and lung cancer consistent with the literature, further studies with larger samples focusing on exposures are needed to better understand the occupational lung cancer burden in Iran.All data relevant to the study are included in the article or uploaded as supplementary information.