TY - JOUR T1 - Lung cancer risk in relation to jobs held in a nationwide case–control study in Iran JF - Occupational and Environmental Medicine JO - Occup Environ Med DO - 10.1136/oemed-2022-108463 SP - oemed-2022-108463 AU - Bayan Hosseini AU - Ann Olsson AU - Liacine Bouaoun AU - Amy Hall AU - Maryam Hadji AU - Hamideh Rashidian AU - Ahmad Naghibzadeh-Tahami AU - Maryam Marzban AU - Farid Najafi AU - Ali Akbar Haghdoost AU - Paolo Boffetta AU - Farin Kamangar AU - Eero Pukkala AU - Arash Etemadi AU - Elisabete Weiderpass AU - Joachim Schüz AU - Kazem Zendehdel Y1 - 2022/09/07 UR - http://oem.bmj.com/content/early/2022/09/06/oemed-2022-108463.abstract N2 - Background Globally, lung cancer is the most frequent occupational cancer, but the risk associated with the occupations or occupational environment in Iran is not clear. We aimed to assess occupations with the risk of lung cancer.Methods We used the IROPICAN nationwide case–control study data including 658 incident lung cancer cases and 3477 controls. We assessed the risk of lung cancer in relation to ever working in major groups of International Standard Classification of Occupations, high-risk occupations for lung cancer and duration of employment and lung cancer subtype among construction workers and farmers while controlling for cigarette smoking and opium consumption. We used unconditional regression logistic models to estimate ORs for the association between increased lung cancer risk and occupations.Results We observed elevated ORs for lung cancer in male construction workers (OR=1.4; 95% CI: 1.0 to 1.8), petroleum industry workers (OR=3.2; 95% CI: 1.1 to 9.8), female farmers (OR=2.6; 95% CI: 1.3 to 5.3) and female bakers (OR=5.5; 95% CI: 1.0 to 29.8). A positive trend by the duration of employment was observed for male construction workers (p< 0.001). Increased risk of squamous cell carcinoma was observed in male construction workers (OR=1.9; 95% CI: 1.2 to 3.0) and female farmers (OR=4.3; 95% CI: 1.1 to 17.2), who also experienced an increased risk of adenocarcinoma (OR=3.8; 95% CI: 1.4 to 9.9).Discussion Although we observed associations between some occupations and lung cancer consistent with the literature, further studies with larger samples focusing on exposures are needed to better understand the occupational lung cancer burden in Iran.All data relevant to the study are included in the article or uploaded as supplementary information. ER -