RT Journal Article
SR Electronic
T1 Night work, chronotype and risk of endometrial cancer in the Screenwide case–control study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 624
OP 627
DO 10.1136/oemed-2021-108080
VO 79
IS 9
A1 Laura Costas
A1 Jon Frias-Gomez
A1 Yolanda Benavente Moreno
A1 Paula Peremiquel-Trillas
A1 Álvaro Carmona
A1 Javier de Francisco
A1 Victor Caño
A1 Sonia Paytubi
A1 Beatriz Pelegrina
A1 José Manuel Martínez
A1 Marta Pineda
A1 Joan Brunet
A1 August Vidal
A1 Xavier Matias-Guiu
A1 Xavier Bosch
A1 Jordi Ponce
A1 Manolis Kogevinas
A1 Silvia De Sanjosé
A1 Laia Alemany
YR 2022
UL http://oem.bmj.com/content/79/9/624.abstract
AB Background Circadian disruption caused by night work has been associated with hormonal-related cancers such as breast and prostate cancer. Data on the role of circadian factors in the aetiology of endometrial cancer, an oestrogen-associated cancer, are scarce.Methods We examined the association between endometrial cancer and night shift work, chronotype (a characteristic correlating with preference for morning or evening activity) and sleep duration, in 180 incident cases and 218 hospital controls. Participants were interviewed face-to-face by trained interviewers to collect information on sociodemographic factors, familial, medical, occupational history (including work shifts), sleep duration and chronotype, and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate ORs and 95% CIs.Results After adjustment by potential confounders, we found an inverse not statistically significant association between ever worked in night shifts and endometrial cancer (OR=0.64; 95% CI=0.35 to 1.16). Associations were irrespective of shift type (permanent or rotating nights) or duration of night work. We did not observe any statistically significant association between endometrial cancer and sleep duration, while inconsistent patterns were observed for chronotype and endometrial cancer risk.Conclusions These data do not support a role for circadian disruption in the carcinogenesis of endometrial cancer.Data are available upon reasonable request.