TY - JOUR T1 - Night work, chronotype and risk of endometrial cancer in the Screenwide case–control study JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 624 LP - 627 DO - 10.1136/oemed-2021-108080 VL - 79 IS - 9 AU - Laura Costas AU - Jon Frias-Gomez AU - Yolanda Benavente Moreno AU - Paula Peremiquel-Trillas AU - Álvaro Carmona AU - Javier de Francisco AU - Victor Caño AU - Sonia Paytubi AU - Beatriz Pelegrina AU - José Manuel Martínez AU - Marta Pineda AU - Joan Brunet AU - August Vidal AU - Xavier Matias-Guiu AU - Xavier Bosch AU - Jordi Ponce AU - Manolis Kogevinas AU - Silvia De Sanjosé AU - Laia Alemany Y1 - 2022/09/01 UR - http://oem.bmj.com/content/79/9/624.abstract N2 - Background Circadian disruption caused by night work has been associated with hormonal-related cancers such as breast and prostate cancer. Data on the role of circadian factors in the aetiology of endometrial cancer, an oestrogen-associated cancer, are scarce.Methods We examined the association between endometrial cancer and night shift work, chronotype (a characteristic correlating with preference for morning or evening activity) and sleep duration, in 180 incident cases and 218 hospital controls. Participants were interviewed face-to-face by trained interviewers to collect information on sociodemographic factors, familial, medical, occupational history (including work shifts), sleep duration and chronotype, and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate ORs and 95% CIs.Results After adjustment by potential confounders, we found an inverse not statistically significant association between ever worked in night shifts and endometrial cancer (OR=0.64; 95% CI=0.35 to 1.16). Associations were irrespective of shift type (permanent or rotating nights) or duration of night work. We did not observe any statistically significant association between endometrial cancer and sleep duration, while inconsistent patterns were observed for chronotype and endometrial cancer risk.Conclusions These data do not support a role for circadian disruption in the carcinogenesis of endometrial cancer.Data are available upon reasonable request. ER -