TY - JOUR T1 - Night shift work and lymphoma: results from an Italian multicentre case–control study JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 452 LP - 459 DO - 10.1136/oemed-2021-107845 VL - 79 IS - 7 AU - Pierluigi Cocco AU - Sara Piro AU - Federico Meloni AU - Andrea Montagna AU - Michele Pani AU - Ilaria Pilia AU - Marina Padoan AU - Lucia Miligi AU - Corrado Magnani AU - Angela Gambelunghe AU - Giacomo Muzi AU - Giovanni Maria Ferri AU - Luigi Vimercati AU - Roberta Zanotti AU - Aldo Scarpa AU - Mariagrazia Zucca AU - Gian Carlo Latte AU - Emanuele Angelucci AU - Sara De Matteis AU - Monica Puligheddu Y1 - 2022/07/01 UR - http://oem.bmj.com/content/79/7/452.abstract N2 - Background Night shift work can disrupt circadian rhythm and cause chronic sleep deprivation, which might increase the risk of lymphoma through immunosuppression and oxidative stress.Material and methods We investigated the association between night shift work and risk of lymphoma subtypes in 867 incident cases and 774 controls, who participated in a multicentre Italian study between 2011 and 2017. Based on questionnaire information, occupational experts assessed the lifetime probability of night shift work, the total number of night shifts and years of night shift work among study participants. OR and 95% CI for lymphoma and its major subtypes associated with night shift work was calculated with logistic regression, adjusting by age, gender, education, study area, marital status and family history of haemolymphatic cancer.Results Ever working night shifts was associated with an increase in the risk of chronic lymphocytic leukaemia (CLL) (OR 1.9, 95% CI 1.14 to 3.32), which was highest after a 15–34 years latency. However, there was not a linear increase in risk by probability of exposure, years of night shift work, nor lifetime number of night shifts whether under rotating or permanent work schedules. Risk of lymphoma overall, B cell lymphoma (BCL), its major subtypes other than CLL, and other less prevalent BCL subtypes combined did not show an association.Conclusions We found conflicting evidence of an association between night shift work and the risk of CLL. We did not observe an association with other lymphoma subtypes.Data are available on reasonable request. Data are preserved in the digital archives of the Department of Medical Sciences and Public Health of the Cagliari University in aggregated form, and they are publicly available as such. Please contact PC (pcocco@unica.it) for any requests. ER -