PT  - JOURNAL ARTICLE
AU  - Miora Valérie Andrianjafimasy
AU  - Mickaël Febrissy
AU  - Farid Zerimech
AU  - Brigitte Dananché
AU  - Hans Kromhout
AU  - Régis Matran
AU  - Mohamed Nadif
AU  - Dominique Oberson-Geneste
AU  - Catherine Quinot
AU  - Vivi Schlünssen
AU  - Valérie Siroux
AU  - Jan-Paul Zock
AU  - Nicole Le Moual
AU  - Rachel Nadif
AU  - Orianne Dumas
TI  - Association between occupational exposure to irritant agents and a distinct asthma endotype in adults
AID  - 10.1136/oemed-2020-107065
DP  - 2022 Mar 01
TA  - Occupational and Environmental Medicine
PG  - 155--161
VI  - 79
IP  - 3
4099  - http://oem.bmj.com/content/79/3/155.short
4100  - http://oem.bmj.com/content/79/3/155.full
SO  - Occup Environ Med2022 Mar 01; 79
AB  - Aim The biological mechanisms of work-related asthma induced by irritants remain unclear. We investigated the associations between occupational exposure to irritants and respiratory endotypes previously identified among never asthmatics (NA) and current asthmatics (CA) integrating clinical characteristics and biomarkers related to oxidative stress and inflammation.Methods We used cross-sectional data from 999 adults (mean 45 years old, 46% men) from the case-control and familial Epidemiological study on the Genetics and Environments of Asthma (EGEA) study. Five respiratory endotypes have been identified using a cluster-based approach: NA1 (n=463) asymptomatic, NA2 (n=169) with respiratory symptoms, CA1 (n=50) with active treated adult-onset asthma, poor lung function, high blood neutrophil counts and high fluorescent oxidation products level, CA2 (n=203) with mild middle-age asthma, rhinitis and low immunoglobulin E level, and CA3 (n=114) with inactive/mild untreated allergic childhood-onset asthma. Occupational exposure to irritants during the current or last held job was assessed by the updated occupational asthma-specific job-exposure matrix (levels of exposure: no/medium/high). Associations between irritants and each respiratory endotype (NA1 asymptomatic as reference) were studied using logistic regressions adjusted for age, sex and smoking status.Results Prevalence of high occupational exposure to irritants was 7% in NA1, 6% in NA2, 16% in CA1, 7% in CA2 and 10% in CA3. High exposure to irritants was associated with CA1 (adjusted OR aOR, (95% CI) 2.7 (1.0 to 7.3)). Exposure to irritants was not significantly associated with other endotypes (aOR range: 0.8 to 1.5).Conclusion Occupational exposure to irritants was associated with a distinct respiratory endotype suggesting oxidative stress and neutrophilic inflammation as potential associated biological mechanisms.No data are available. Due to third party restrictions, EGEA data are not publicly available. Please see the following URL for more information: https://egeanet.vjf.inserm.fr/index.php/en/contacts-enInterested researchers should contact egea.cohorte@inserm.fr with further questions regarding data access.