RT Journal Article
SR Electronic
T1 Night shift work and lymphoma: results from an Italian multicentre case–control study
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP oemed-2021-107845
DO 10.1136/oemed-2021-107845
A1 Pierluigi Cocco
A1 Sara Piro
A1 Federico Meloni
A1 Andrea Montagna
A1 Michele Pani
A1 Ilaria Pilia
A1 Marina Padoan
A1 Lucia Miligi
A1 Corrado Magnani
A1 Angela Gambelunghe
A1 Giacomo Muzi
A1 Giovanni Maria Ferri
A1 Luigi Vimercati
A1 Roberta Zanotti
A1 Aldo Scarpa
A1 Mariagrazia Zucca
A1 Gian Carlo Latte
A1 Emanuele Angelucci
A1 Sara De Matteis
A1 Monica Puligheddu
YR 2022
UL http://oem.bmj.com/content/early/2022/01/12/oemed-2021-107845.abstract
AB Background Night shift work can disrupt circadian rhythm and cause chronic sleep deprivation, which might increase the risk of lymphoma through immunosuppression and oxidative stress.Material and methods We investigated the association between night shift work and risk of lymphoma subtypes in 867 incident cases and 774 controls, who participated in a multicentre Italian study between 2011 and 2017. Based on questionnaire information, occupational experts assessed the lifetime probability of night shift work, the total number of night shifts and years of night shift work among study participants. OR and 95% CI for lymphoma and its major subtypes associated with night shift work was calculated with logistic regression, adjusting by age, gender, education, study area, marital status and family history of haemolymphatic cancer.Results Ever working night shifts was associated with an increase in the risk of chronic lymphocytic leukaemia (CLL) (OR 1.9, 95% CI 1.14 to 3.32), which was highest after a 15–34 years latency. However, there was not a linear increase in risk by probability of exposure, years of night shift work, nor lifetime number of night shifts whether under rotating or permanent work schedules. Risk of lymphoma overall, B cell lymphoma (BCL), its major subtypes other than CLL, and other less prevalent BCL subtypes combined did not show an association.Conclusions We found conflicting evidence of an association between night shift work and the risk of CLL. We did not observe an association with other lymphoma subtypes.Data are available on reasonable request. Data are preserved in the digital archives of the Department of Medical Sciences and Public Health of the Cagliari University in aggregated form, and they are publicly available as such. Please contact PC (pcocco@unica.it) for any requests.