TY - JOUR T1 - Integrating vocational rehabilitation and mental healthcare to improve the return-to-work process for people on sick leave with depression or anxiety: results from a three-arm, parallel randomised trial JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 134 LP - 142 DO - 10.1136/oemed-2021-107894 VL - 79 IS - 2 AU - Andreas Hoff AU - Rie Mandrup Poulsen AU - Jonas Fisker AU - Carsten Hjorthøj AU - Nicole Rosenberg AU - Merete Nordentoft AU - Anders Bo Bojesen AU - Lene Falgaard Eplov Y1 - 2022/02/01 UR - http://oem.bmj.com/content/79/2/134.abstract N2 - Objective The aim of this study was to investigate an integrated mental healthcare and vocational rehabilitation intervention to improve and hasten the process of return-to-work of people on sick leave with anxiety and depression.Methods In this three-arm, randomised trial, participants were assigned to (1) integrated intervention (INT), (2) improved mental healthcare (MHC) or (3) service as usual (SAU). The primary outcome was time to return-to-work measured at 12-month follow-up. The secondary outcomes were time to return-to-work measured at 6-month follow-up; levels of anxiety, depression, stress symptoms, and social and occupational functioning at 6 months; and return-to-work measured as proportion in work at 12 months.Results 631 individuals were randomised. INT yielded a higher proportion in work compared with both MHC (56.2% vs 43.7%, p=0.012) and SAU (56.2% vs 45%, p=0.029) at 12-month follow-up. We found no differences in return-to-work in terms of sick leave duration at either 6-month or 12-month follow-up, with the latter being the primary outcome. No differences in anxiety, depression or functioning between INT, MHC and SAU were identified, but INT and MHC showed lower scores on Cohen’s Perceived Stress Scale compared with SAU at 6-month follow-up.Conclusions Although INT did not hasten the process of return-to-work, it yielded better outcome with regard to proportion in work compared with MHC and SAU. The findings suggest that INT compared with SAU is associated with a few, minor health benefits. Overall, INT yielded slightly better vocational and health outcomes, but the clinical significance of the health advantage is questionable.Trial registration number NCT02872051.Data are available upon reasonable request. Data can be shared by contacted the corresponding author, including individual participant data and a data dictionary. Data can include all data used for calculating all outcomes in the study, and all relevant data for assessing eligibility for referred patients. Such data sharing requires an application stating purpose of data retrieval in details. Furthermore, a data sharing agreement is required, and this should without exceptions live up to the requirements of EU The General Data Protection Regulation 2016/679 (GDPR). ER -