@article {Leidi116, author = {Antonio Leidi and Amandine Berner and Roxane Dumont and Richard Dubos and Flora Koegler and Giovanni Piumatti and Nicolas Vuilleumier and Laurent Kaiser and Jean-Fran{\c c}ois Balavoine and Didier Trono and Didier Pittet and Fran{\c c}ois Chappuis and Omar Kherad and Delphine Sophie Courvoisier and Andrew S Azman and Maria Eugenia Zaballa and Idris Guessous and Silvia Stringhini}, editor = {, and , and Alber, Victoria and Arm-Vernez, Isabelle and Azman, Andrew S and Bachmann, Delphine and Bachmann, Donatien and Baggio, St{\'e}phanie and Balavoine, Jean-Fran{\c c}ois and Monteiro, Gil Barbosa and Baysson, H{\'e}l{\`e}ne and Bleich, Patrick and Boissel, Isabelle and Chappuis, Fran{\c c}ois and Collombet, Prune and Courvoisier, Delphine and Couson, Philippine and Davidovic, Alioucha and Deiri, Clement and Rio, Divina Del and Mestral, Carlos de and Ridder, David De and Dibner, Yaron and D{\textquoteright}Ippolito, Paola and Duc, Jos{\'e}phine and Dumont, Roxane and Eckerle, Isabella and Merjani, Nacira El and Ferniot, Gwennaelle and Flahault, Antonie and Francioli, Natalie and Frangville, Marion and Garande, Carine and G{\'e}taz, Laurent and Giraldo, Pamela and Golaz, Fanny and Gu{\'e}rin, Julie and Guessous, Idris and Haboury, Ludivine and Harnal, S{\'e}verine and Javet, Victoria and Kaiser, Laurent and Kherad, Omar and Laboulais, Am{\'e}lie and Lamour, Ga{\"e}lle and Lefebvre, Xavier and Lescuyer, Pierre and Loizeau, Andrea Jutta and Lombard, Fanny-Blanche and Lorthe, Elsa and Martinez, Chantal and Massiha, Kourosh and Metral-Boffod, Ludovic and Meyer, Benjamin and Mostaguir, Khaled and Nehme, Mayssam and No{\"e}l, Natacha and Oederlin, Nicolas and Pennacchio, Francesco and Perez-Saez, Javier and Petrovic, Dusan and Picazio, Attilio and Pittet, Didier and Piumatti, Giovanni and Portier, Jane and Poulain, G{\'e}raldine and Pugin, Caroline and Pullen, Nick and Rakotomiaramanana, Barinjaka and Randrianandrasana, Zo Francia and Richard, Aude and Richard, Viviane and Rodriguez-Velazquez, Sabina and Salzmann-Bellard, Lilas and Stringhini, Silvia and Thorens, Leonard and Torroni, Simon and Trono, Didier and Vidonne, David and Violot, Guillemette and Vuilleumier, Nicolas and Waldmann, Zo{\'e} and Will, Manon and Wisniak, Ania and Yerly, Sabine and Zaballa, Mar{\'\i}a-Eugenia}, title = {Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study}, volume = {79}, number = {2}, pages = {116--119}, year = {2022}, doi = {10.1136/oemed-2021-107924}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objectives This cohort study including essential workers, assessed the risk and incidence of SARS-CoV-2 infection during the second surge of COVID-19 according to baseline serostatus and occupational sector.Methods Essential workers were selected from a seroprevalence survey cohort in Geneva, Switzerland and were linked to a state centralised registry compiling SARS-CoV-2 infections. Primary outcome was the incidence of virologically confirmed infections from serological assessment (between May and September 2020) to 25 January 2021, according to baseline antibody status and stratified by three predefined occupational groups (occupations requiring sustained physical proximity, involving brief regular contact or others).Results 10 457 essential workers were included (occupations requiring sustained physical proximity accounted for 3057 individuals, those involving regular brief contact, 3645 and 3755 workers were classified under {\textquoteleft}Other essential occupations{\textquoteright}). After a follow-up period of over 27 weeks, 5 (0.6\%) seropositive and 830 (8.5\%) seronegative individuals had a positive SARS-CoV-2 test, with an incidence rate of 0.2 (95\% CI 0.1 to 0.6) and 3.2 (95\% CI 2.9 to 3.4) cases per person-week, respectively. Incidences were similar across occupational groups. Seropositive essential workers had a 93\% reduction in the hazard (HR of 0.07, 95\% CI 0.03 to 0.17) of having a positive test during the follow-up with no significant between-occupational group difference.Conclusions A 10-fold reduction in the hazard of being virologically tested positive was observed among anti-SARS-CoV-2 seropositive essential workers regardless of their sector of occupation, confirming the seroprotective effect of a previous SARS-CoV2 exposure at least 6 months after infection.Data are available on reasonable request.}, issn = {1351-0711}, URL = {https://oem.bmj.com/content/79/2/116}, eprint = {https://oem.bmj.com/content/79/2/116.full.pdf}, journal = {Occupational and Environmental Medicine} }