TY - JOUR T1 - Temporal association of prostate cancer incidence with World Trade Center rescue/recovery work JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - 699 LP - 706 DO - 10.1136/oemed-2021-107405 VL - 78 IS - 10 AU - David G Goldfarb AU - Rachel Zeig-Owens AU - Dana Kristjansson AU - Jiehui Li AU - Robert M Brackbill AU - Mark R Farfel AU - James E Cone AU - Janette Yung AU - Amy R Kahn AU - Baozhen Qiao AU - Maria J Schymura AU - Mayris P Webber AU - Christopher R Dasaro AU - Moshe Shapiro AU - Andrew C Todd AU - David J Prezant AU - Paolo Boffetta AU - Charles B Hall Y1 - 2021/10/01 UR - http://oem.bmj.com/content/78/10/699.abstract N2 - Background The World Trade Center (WTC) attacks on 11 September 2001 created a hazardous environment with known and suspected carcinogens. Previous studies have identified an increased risk of prostate cancer in responder cohorts compared with the general male population.Objectives To estimate the length of time to prostate cancer among WTC rescue/recovery workers by determining specific time periods during which the risk was significantly elevated.Methods Person-time accruals began 6 months after enrolment into a WTC cohort and ended at death or 12/31/2015. Cancer data were obtained through linkages with 13 state cancer registries. New York State was the comparison population. We used Poisson regression to estimate hazard ratios and 95% CIs; change points in rate ratios were estimated using profile likelihood.Results The analytic cohort included 54 394 male rescue/recovery workers. We observed 1120 incident prostate cancer cases. During 2002–2006, no association with WTC exposure was detected. Beginning in 2007, a 24% increased risk (HR: 1.24, 95% CI 1.16 to 1.32) was observed among WTC rescue/recovery workers when compared with New York State. Comparing those who arrived earliest at the disaster site on the morning of 11 September 2001 or any time on 12 September 2001 to those who first arrived later, we observed a positive, monotonic, dose-response association in the early (2002–2006) and late (2007–2015) periods.Conclusions Risk of prostate cancer was significantly elevated beginning in 2007 in the WTC combined rescue/recovery cohort. While unique exposures at the disaster site might have contributed to the observed effect, screening practices including routine prostate specific antigen screening cannot be discounted.Data are available on reasonable request. Data that support the findings of the study may be obtained from the corresponding author (CBH) upon reasonable request after approval by the Steering Committee for 'Incidence, Latency and Survival of Cancer Following World Trade Center Exposure' (NIOSH Cooperative Agreement U01 OH011932) in accordance with the study’s official Data Sharing Plan. ER -