PT  - JOURNAL ARTICLE
AU  - Olia Archangelidi
AU  - Sean Sathiyajit
AU  - Dario Consonni
AU  - Debbie Jarvis
AU  - Sara De Matteis
TI  - Cleaning products and respiratory health outcomes in occupational cleaners: a systematic review and meta-analysis
AID  - 10.1136/oemed-2020-106776
DP  - 2021 Aug 01
TA  - Occupational and Environmental Medicine
PG  - 604--617
VI  - 78
IP  - 8
4099  - http://oem.bmj.com/content/78/8/604.short
4100  - http://oem.bmj.com/content/78/8/604.full
SO  - Occup Environ Med2021 Aug 01; 78
AB  - There is consistent evidence of increased respiratory symptoms in occupational cleaners; however, uncertainty remains on type of respiratory health effects, underlying causal agents, mechanisms and respiratory phenotypes. We aimed to conduct a systematic review and if possible, a meta-analysis of the available literature to characterise and quantify the cleaning-related respiratory health effects. We searched MEDLINE and EMBASE databases and included studies that evaluated the association of any respiratory health outcome with exposure to cleaning occupation or products in occupational cleaners. A modified GRADE was used to appraise the quality of included studies. We retrieved 1124 articles, and after applying our inclusion criteria, 39 were selected for the systematic review. We performed a meta-analysis of the 21 studies evaluating asthma which showed a 50% increased pooled relative risk in cleaners (meta-relative risk (RR)=1.50; 95% CI 1.44 to 1.56). Population-based cross-sectional studies showed more stable associations with asthma risk. No evidence of atopic asthma as dominant phenotype emerged. Also, we estimated a 43% increased risk (meta-RR=1.43; 95% CI 1.31 to 1.56) of chronic obstructive pulmonary disease. Evidence for associations with bronchial-hyper-responsiveness, lung function decline, rhinitis, upper and lower respiratory tract symptoms was weaker. In our systematic review and meta-analysis, we found that working as a cleaner is associated with an increased risk of reversible and even irreversible obstructive airway diseases. All studies lacked quantitative exposure assessment to cleaning products; this would help elucidate underlying causal agents and mechanisms. Exposure control and respiratory surveillance among cleaners is warranted to prevent the associated respiratory health burden. Trial registration number: CRD4201705915.