PT  - JOURNAL ARTICLE
AU  - Jingyi Qin
AU  - Wei Xia
AU  - Gaodao Liang
AU  - Shunqing Xu
AU  - Xiuge Zhao
AU  - Danlu Wang
AU  - Xiaojie Sun
AU  - Yuanyuan Li
AU  - Hongxiu Liu
TI  - Association of fine particulate matter with glucose and lipid metabolism: a longitudinal study in young adults
AID  - 10.1136/oemed-2020-107039
DP  - 2021 Jun 01
TA  - Occupational and Environmental Medicine
PG  - 448--453
VI  - 78
IP  - 6
4099  - http://oem.bmj.com/content/78/6/448.short
4100  - http://oem.bmj.com/content/78/6/448.full
SO  - Occup Environ Med2021 Jun 01; 78
AB  - Objectives This study aimed to evaluate whether PM2.5 exposure in a highly polluted area (>100 µg/m3) affects glucose and lipid metabolism in healthy adults.Methods We recruited 110 healthy adults in Baoding city, Hebei, China, and followed them up between 2017 and 2018. Personal air samplers were used to monitor personal PM2.5 levels. Eight glucose and lipid metabolism parameters were quantified. We performed the linear mixed-effect models to investigate the relationships between PM2.5 and glucose and lipid metabolism parameters. Stratified analyses were further performed according to sex and body mass index (BMI).Results The concentration of PM2.5 was the highest in spring, with a median of 232 μg/m3 and the lowest in autumn (139 μg/m3). After adjusting for potential confounders, we found that for each twofold increase in PM2.5, the median of insulin concentration decreased by 5.89% (95% CI −10.91% to −0.58%; p<0.05), and ox-LDL increased by 6.43% (95% CI 2.21% to 10.82%; p<0.05). Stratified analyses indicated that the associations were more pronounced in females, overweight and obese participants.Conclusions Exposure to high PM2.5 may have deleterious effects on glucose and lipid metabolism. Females, overweight and obese participants are more vulnerable.There are no data in this work.