RT Journal Article
SR Electronic
T1 Lung cancer risk in painters: results from the SYNERGY pooled case–control study consortium
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 269
OP 278
DO 10.1136/oemed-2020-106770
VO 78
IS 4
A1 Guha, Neela
A1 Bouaoun, Liacine
A1 Kromhout, Hans
A1 Vermeulen, Roel
A1 Brüning, Thomas
A1 Behrens, Thomas
A1 Peters, Susan
A1 Luzon, Véronique
A1 Siemiatycki, Jack
A1 Xu, Mengting
A1 Kendzia, Benjamin
A1 Guenel, Pascal
A1 Luce, Danièle
A1 Karrasch, Stefan
A1 Wichmann, Heinz-Erich
A1 Consonni, Dario
A1 Landi, Maria Teresa
A1 Caporaso, Neil E
A1 Gustavsson, Per
A1 Plato, Nils
A1 Merletti, Franco
A1 Mirabelli, Dario
A1 Richiardi, Lorenzo
A1 Jöckel, Karl-Heinz
A1 Ahrens, Wolfgang
A1 Pohlabeln, Hermann
A1 TSE, Lap Ah
A1 Yu, Ignatius Tak-Sun
A1 Tardón, Adonina
A1 Boffetta, Paolo
A1 Zaridze, David
A1 't Mannetje, Andrea
A1 Pearce, Neil
A1 Davies, Michael P A
A1 Lissowska, Jolanta
A1 Świątkowska, Beata
A1 McLaughlin, John
A1 Demers, Paul A
A1 Bencko, Vladimir
A1 Foretova, Lenka
A1 Janout, Vladimir
A1 Pándics, Tamás
A1 Fabianova, Eleonora
A1 Mates, Dana
A1 Forastiere, Francesco
A1 Bueno-de-Mesquita, Bas
A1 Schüz, Joachim
A1 Straif, Kurt
A1 Olsson, Ann
YR 2021
UL http://oem.bmj.com/content/78/4/269.abstract
AB Objectives We evaluated the risk of lung cancer associated with ever working as a painter, duration of employment and type of painter by histological subtype as well as joint effects with smoking, within the SYNERGY project.Methods Data were pooled from 16 participating case–control studies conducted internationally. Detailed individual occupational and smoking histories were available for 19 369 lung cancer cases (684 ever employed as painters) and 23 674 age-matched and sex-matched controls (532 painters). Multivariable unconditional logistic regression models were adjusted for age, sex, centre, cigarette pack-years, time-since-smoking cessation and lifetime work in other jobs that entailed exposure to lung carcinogens.Results Ever having worked as a painter was associated with an increased risk of lung cancer in men (OR 1.30; 95% CI 1.13 to 1.50). The association was strongest for construction and repair painters and the risk was elevated for all histological subtypes, although more evident for small cell and squamous cell lung cancer than for adenocarcinoma and large cell carcinoma. There was evidence of interaction on the additive scale between smoking and employment as a painter (relative excess risk due to interaction >0).Conclusions Our results by type/industry of painter may aid future identification of causative agents or exposure scenarios to develop evidence-based practices for reducing harmful exposures in painters.