RT Journal Article SR Electronic T1 P.1.21 The establishment of a cohort study in a semiconductor company of south korea JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP A82 OP A83 DO 10.1136/OEM-2019-EPI.224 VO 76 IS Suppl 1 A1 Lee, Jiae A1 Lee, Gyeongho A1 Jung, Woojin A1 Kim, Enjung A1 Kim, Gawon A1 Na, Wonwoong A1 Lee, Saeyoung YR 2019 UL http://oem.bmj.com/content/76/Suppl_1/A82.4.abstract AB We have designed a ten-year prospective cohort study in semiconductor workers of South Korea. We aimed to determine the relationship between occupational exposure and not only cancers but also diseases related to reproductive toxicity such as spontaneous abortion and others. Further, we’re planning to establish a monitoring and surveillance system for the known and the unknown hazards like unexpected by-products. We were approved from Korea National Institute for Bioethics Policy (KoNIBP) for cohort establishment in July 2017. We held cohort information session of over two hundred times for entire employees. In these sessions, the employees were encouraged to participate to the cohort study with full explanation related to the establishment of cohort system including the necessity, value, and vision of the system. The consent form was included specific sub-categories depending on the characteristics and source of personal and sensitive information to be used. A total of 22 490 employees were agreed to participate to SHE (SKHynix Employees) cohort (the participation rate: 93 percent) and we built up the foundation of the cohort with these higher rates. Various data included in the consent form, such as personnel information, health examination information, and job exposure matrix (JEM) and others were collected and refined to identify health status of our employees. The cohort was built on the basis of the need of our own healthcare system, and the establishment and the analyses of cohort DB are expected to deduct of the high risk group through tracking and monitoring for risk factors and major diseases. It is also expected proactive prevention through blocking potential risks.