RT Journal Article SR Electronic T1 Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP oemed-2018-105469 DO 10.1136/oemed-2018-105469 A1 Aisha S Dickerson A1 Johnni Hansen A1 Aaron J Specht A1 Ole Gredal A1 Marc G Weisskopf YR 2019 UL http://oem.bmj.com/content/early/2019/01/31/oemed-2018-105469.abstract AB Objectives Previous research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS.Methods ALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex.Results For men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex.Conclusions Our study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.