@article {Adler71, author = {Colin Adler and Melissa C Friesen and Edward D Yeboah and Yao Tettey and Richard B Biritwum and Andrew A Adjei and Evelyn Tay and Victoria Okyne and James E Mensah and Ann Truelove and Baiyu Yang and Scott P Kelly and Cindy Ke Zhou and Lauren E McCullough and Larissa Pardo and Robert N Hoover and Ann W Hsing and Michael B Cook and Stella Koutros}, title = {Usual adult occupation and risk of prostate cancer in West African men: the Ghana Prostate Study}, volume = {76}, number = {2}, pages = {71--77}, year = {2019}, doi = {10.1136/oemed-2018-105391}, publisher = {BMJ Publishing Group Ltd}, abstract = {Objectives Established prostate cancer (PCa) risk factors include age, family history of PCa and African ancestry. Studies, mostly among highly screened, predominantly European ancestral populations, suggest that employment in certain occupations (eg, farming, military) may also have an increased risk for PCa. Here, we evaluated the association between usual adult occupation and PCa risk in Ghanaian men, a population with historically low rates of PCa screening.Methods The Ghana Prostate Study is a case-control study of PCa that was conducted from 2004 to 2012 in 749 cases and 964 controls. In-person interviews were conducted to collect information from participants, including longest held job. Industrial hygienists classified job titles into occupational categories. Unconditional logistic regression was used to calculate ORs and 95\% CIs for the association between longest held job and PCa risk (overall, aggressive (Gleason>=7)), controlling for potential confounders.Results Risk was increased among men in management (overall PCa OR=2.2, 95\% CI 1.4 to 3.2; aggressive PCa OR=2.2, 95\% CI 1.3 to 3.5) and military occupations (overall PCa OR=3.4, 95\% CI 1.7 to 7.0; aggressive PCa OR=3.5, 95\% CI 1.5 to 8.3). Risks were also elevated for management and military-specific jobs based on 3-digit level Standard Occupational Classification definitions. Sensitivity analyses accounting for access to medical care did not show significant differences.Conclusions Our study provides some evidence for increased risk of PCa among men in management and military occupations, which is consistent with the published literature. Additional research is needed to clarify the drivers of the associations between these occupations and PCa.}, issn = {1351-0711}, URL = {https://oem.bmj.com/content/76/2/71}, eprint = {https://oem.bmj.com/content/76/2/71.full.pdf}, journal = {Occupational and Environmental Medicine} }