RT Journal Article SR Electronic T1 Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP 412 OP 414 DO 10.1136/oemed-2017-104974 VO 75 IS 6 A1 Nissen, Mette Schou A1 Stokholm, Zara Ann A1 Christensen, Mette Skovgaard A1 Schlünssen, Vivi A1 Vestergaard, Jesper Medom A1 Iversen, Inge Brosbøl A1 Kolstad, Henrik Albert YR 2018 UL http://oem.bmj.com/content/75/6/412.abstract AB Background Sinonasal adenocarcinoma is a rare disease expected to have rare causes and potential for strong risk factors as reflected by the strong association with occupational wood dust exposure. High level styrene exposure is a rare and suspected carcinogen, and this study examines the exposure–response relation between occupational styrene exposure, sinonasal adenocarcinoma and other subtypes.Methods We followed 73 092 styrene-exposed workers from 1968 to 2011 and identified sinonasal cancers in the Danish Cancer Registry. We modelled cumulative styrene exposure and estimated incidence rates and age, sex and wood-industry adjusted ORs.Results During 1 585 772 person-years, we observed nine cases of adenocarcinoma, corresponding to a fivefold non-significantly increased OR for estimates of high versus low cumulative styrene exposure (OR 5.11, 95% CI 0.58 to 45.12). The increased risk was confined to exposure received during the recent 15 years. The other histological subtypes showed no increased risk.Conclusion This study suggests increased risk of sinonasal adenocarcinoma following styrene exposure. The observations are, however, few, confounding from wood dust exposure cannot be ruled out, and additional studies are needed before firm conclusions can be drawn.