TY - JOUR T1 - 949 Shiftwork and breast cancer: epidemiology, burden, and implications for prevention JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - A490 LP - A490 DO - 10.1136/oemed-2018-ICOHabstracts.1395 VL - 75 IS - Suppl 2 AU - Manisha Pahwa AU - France Labrèche AU - M Anne Harris AU - Joanne Kim AU - Chaojie Song AU - Paul A Demers Y1 - 2018/04/01 UR - http://oem.bmj.com/content/75/Suppl_2/A490.1.abstract N2 - Introduction Approximately one in five workers globally work night, evening, or rotating shifts. Shiftwork involving circadian disruption is a probable carcinogen for breast cancer. Our objective was to synthesise the current state of the epidemiological literature, report on shiftwork-associated breast cancer burden in Canada, and discuss implications for prevention.Methods A search was conducted for meta-analyses accompanied by a systematic review, published from 2010–2017, that included at least one meta-risk estimate (mRE) for breast cancer associated with any permanent/rotating night work exposure metric. For each included meta-analysis, heterogeneity values were extracted and an eight-point checklist was used to evaluate quality. An attributable fraction (AF) range for breast cancer, based on mREs from high quality meta-analyses and Canadian shiftwork survey data, was calculated using Levin’s equation.Results Seven meta-analyses collectively included 30 cohort and case-control studies spanning 1996–2016. Most reported statistically significant heterogeneity. In 5 meta-analyses that scored ≥6 points on the quality assessment checklist, mREs for ever/never night shiftwork exposure ranged from 1.15 (95% confidence interval [CI]: 1.05 to 1.25, n=9 studies) to 1.40 (95% CI: 1.13 to 1.73, n=9 studies). Using these mREs as lower and upper values in Levin’s equation, the AF for breast cancer among the 1.5 million Canadian women who ever worked night/rotating shifts during 1961–2001 ranged from 2.04%–5.23%. This corresponds to an estimated 460–1180 annual incident breast cancers probably due to shiftwork; nearly half (200–510) are diagnosed among women in health care and social assistance.Discussion Summaries of 20 years of epidemiological evidence support shiftwork as a probable breast carcinogen, but considerable heterogeneity between studies poses a challenge for precisely evaluating breast cancer risk and burden. Given the potentially substantial burden of breast cancer due to shiftwork, applied research on workplace-based prevention of circadian disruption is acutely needed to identify effective solutions for sectors where shiftwork prevalence is high. ER -