TY - JOUR T1 - 1113 Pleural plaques: markers of asbestos exposure or indipendent risk factor for pleural mesothelioma? a case report JF - Occupational and Environmental Medicine JO - Occup Environ Med SP - A456 LP - A457 DO - 10.1136/oemed-2018-ICOHabstracts.1298 VL - 75 IS - Suppl 2 AU - Pietro Sartorelli AU - Gabriele d’Hauw AU - Antonietta Gerardina Sisinni AU - Riccardo Romeo AU - Valentina Paolucci AU - Donatella Spina Y1 - 2018/04/01 UR - http://oem.bmj.com/content/75/Suppl_2/A456.3.abstract N2 - Pleural plaques (PPs) represent the most common non malignant asbestos-related disease. Currently PPs are widely referred as a marker of asbestos exposure and not as an independent risk factor for the development of asbestos-related neoplastic diseases (1). However, the association between PPs and pleural mesothelioma (PM) remains controversial, as some studies on cohorts of asbestos exposed workers have shown correlation between PPs and PM. Despite this, scientific literature is poor. Research has been focused on the relationship between PPs and lung cancer, while there is a lack of studies on the possible relationship between PPs and the development of PM.Case presentation A clinical case of a patient affected by asbestosis and PPs with a history of occupational asbestos exposure is presented. During the follow up a PM was diagnosed at a PP.Conclusions The widespread belief that there is no relationship between PPs and PM is not supported by a vast literature as it happens for the absence of association between PPs and lung cancer. In the patient described it is not possible to determine whether the localization of the PM at a PP is incidental or not and whether the PM can be attributed only to intense exposure or even to the presence of PPs. Similar cases may not be uncommon even if not reported in the literature.References. Maxim LD, Niebo R, Utell MJ. Are pleural plaques an appropriate endpoint for risk analyses?Inhalation Toxicology2015;27:321–334.. Pairon JC, Laurent F, Rinaldo M, Clin B, Andujar P, et al. Pleural plaques and the risk of pleural mesothelioma. JNCI2013;105:293–301. doi:10.1093/jnci/djs513View this table:Abstract 334 Table 1 All apps are free of charge ER -