PT - JOURNAL ARTICLE AU - Orianne Dumas AU - Raphäelle Varraso AU - Krislyn M Boggs AU - Alexis Descatha AU - Paul K Henneberger AU - Catherine Quinot AU - Frank E Speizer AU - Jan-Paul Zock AU - Nicole Le Moual AU - Carlos A Camargo Jr TI - Association of hand and arm disinfection with asthma control in US nurses AID - 10.1136/oemed-2017-104740 DP - 2018 May 01 TA - Occupational and Environmental Medicine PG - 378--381 VI - 75 IP - 5 4099 - http://oem.bmj.com/content/75/5/378.short 4100 - http://oem.bmj.com/content/75/5/378.full SO - Occup Environ Med2018 May 01; 75 AB - Objectives To investigate the association between occupational exposure to disinfectants/antiseptics used for hand hygiene and asthma control in nurses.Methods In 2014, we invited female nurses with asthma drawn from the Nurses’ Health Study II to complete two supplemental questionnaires on their occupation and asthma (cross-sectional study, response rate: 80%). Among 4055 nurses (mean age: 59 years) with physician-diagnosed asthma and asthma medication use in the past year, we examined asthma control, as defined by the Asthma Control Test (ACT). Nurses were asked about the daily frequency of hand hygiene tasks: ‘wash/scrub hands with disinfectants/hand sanitizers’ (hand hygiene) and ‘wash/scrub arms with disinfecting products’ (surrogate of surgical hand/arm antisepsis). Analyses were adjusted for age, race, ethnicity, smoking status and body mass index.Results Nurses with partly controlled asthma (ACT: 20–24, 50%) and poorly controlled asthma (ACT ≤19, 18%) were compared with nurses with controlled asthma (ACT=25, 32%). In separate models, both hand and arm hygiene were associated with poorly controlled asthma. After mutual adjustment, only arm hygiene was associated with poorly controlled asthma: OR (95% CI) for <1 time/day, 1.38 (1.06 to 1.80); ≥1 time/day, 1.96 (1.52 to 2.51), versus never. We observed a consistent dose–response relationship between frequency of arm hygiene tasks (never to >10 times/day) and poor asthma control. Associations persisted after further adjustment for surfaces/instruments disinfection tasks.Conclusions Frequency of hand/arm hygiene tasks in nurses was associated with poor asthma control. The results suggest an adverse effect of products used for surgical hand/arm antisepsis. This potential new occupational risk factor for asthma warrants further study.