RT Journal Article
SR Electronic
T1 The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP 12
OP 22
DO 10.1136/oemed-2016-104280
VO 75
IS 1
A1 Damien M McElvenny
A1 Martie van Tongeren
A1 Michelle C Turner
A1 Geza Benke
A1 Jordi Figuerola
A1 Sarah Fleming
A1 Martine Hours
A1 Laurel Kincl
A1 Daniel Krewski
A1 Dave McLean
A1 Marie-Élise Parent
A1 Lesley Richardson
A1 Brigitte Schlehofer
A1 Klaus Schlaefer
A1 Siegal Sadetzki
A1 Joachim Schüz
A1 Jack Siemiatycki
A1 Elisabeth Cardis
YR 2018
UL http://oem.bmj.com/content/75/1/12.abstract
AB Background Little is known about occupational risk factors for meningioma.Objectives To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents.Methods The INTEROCC study was an international case-control study of brain cancer conducted in seven countries. Data collection by interview included lifetime occupational histories. A job exposure matrix was used to derive estimates of exposure for the 12 agents. ORs for ever versus never exposed and for exposure-response using duration of exposure and cumulative exposure were derived using conditional logistic regression stratified by sex, age group, country/region, adjusted for education.Results These analyses included 1906 cases and 5565 controls. For 11 of the 12 agents, no excess risk was found for ever exposed. For ever exposure to oil mists, an elevated OR of 1.57 (95% CI 1.10 to 2.22, 51 exposed cases) was found. Statistically significant exposure-response relationships were observed with cumulative exposure (p=0.01) and duration of exposure (p=0.04). Among women, there were also significant trends for cumulative and duration of exposure to asbestos and excesses in the highest exposure categories for formaldehyde.Conclusions Most agents examined did not provoke excess risks of meningioma. The main finding from this study is that it is the first study to identify a statistical association between exposure to oil mists and meningioma. This may be a chance finding or could be due to confounding with iron exposure and further research is required to understand whether the relationship is causal.