RT Journal Article SR Electronic T1 Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP 656 OP 662 DO 10.1136/oemed-2016-103769 VO 73 IS 10 A1 Deepika Shrestha A1 Sa Liu A1 S Katharine Hammond A1 Michael P LaValley A1 Daniel E Weiner A1 Ellen A Eisen A1 Katie M Applebaum YR 2016 UL http://oem.bmj.com/content/73/10/656.abstract AB Objectives Metalworking fluids (MWF), used to cool and lubricate metal in occupational settings, are linked to several cancers but data on kidney cancer are limited. We examine how MWF influence the rate of renal cell carcinoma (RCC) in a large prospective study.Methods A cohort of Michigan autoworkers consisting of 33 421 individuals was followed from 1985 to 2009. The cohort was linked to the Michigan Cancer Registry to identify new cases of RCC. We analysed RCC in relation to cumulative exposure to each specific type of MWF (straight, soluble and synthetic) and all 3 types pooled into a single MWF variable, with a 15-year lag. Cox proportional hazards regression with splines were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), controlling for age, gender, race, calendar year, year hired, time since hire, plant and other MWF types.Results There were 135 incident cases. A linear increase in the log-HR was observed for RCC with increasing cumulative exposure to each MWF type and total MWF exposure. At the mean of total MWF exposure (18.80 mg/m3-year), the estimated HR was 1.11 (95% CI 1.04 to 1.19).Conclusions Our results provide evidence for a dose-dependent association between MWF exposure and RCC. The influence of components of oil-based and water-based MWF needs further examination.