RT Journal Article SR Electronic T1 P056 Occupational exposure to metals and risk of breast, chronic lymphocytic leukaemia, colorectal, prostate, and stomach cancer in the MCC-spain case control study JF Occupational and Environmental Medicine JO Occup Environ Med FD BMJ Publishing Group Ltd SP A139 OP A140 DO 10.1136/oemed-2016-103951.379 VO 73 IS Suppl 1 A1 Angela Zumel A1 Juan Alguacil A1 Laura Costas A1 Esther García A1 Miguel Santibáñez A1 Nuria Aragonés A1 Beatriz Pérez-Gómez A1 Tania Fernández-Villa A1 Javier Llorca A1 Victor Moreno A1 Mikel Azpiri A1 Marcela Guevara A1 Silvia de Sanjosé A1 José J Jiménez-Moleón A1 Guillermo Fernández-Tardón A1 Rocío Capelo A1 Rosana Peiró A1 Rafael Marcos-Gragera A1 Jose María Huerta A1 Gemma Castaño-Vinyals A1 Marina Pollán A1 Ana María García A1 Manolis Kogevinas YR 2016 UL http://oem.bmj.com/content/73/Suppl_1/A139.2.abstract AB Arsenic, cadmium, chromium, and nickel are classified by IARC as human carcinogens (Group 1), while lead as a probable/possible carcinogen to humans (Group 2A). We explored associations between occupational exposure to metals and breast, chronic lymphocytic leukaemia (CLL), colorectal, prostate, and stomach cancer in the MCC-Spain population based case-control study.Methods The analyses were based on 3047 controls, and 1499 breast, 1539 colorectal, 332 CLL, 1070 prostate, and 382 stomach cancer cases. Occupational exposure to arsenic, cadmium, chromium, iron, lead and nickel was assessed using the MatEmEsp job-exposure matrix. Logistic regression models accounting for education, sex, geographic area, number of jobs, body mass index (colorectal, prostate), smoking (stomach, colorectal), menopause (breast) and number of alive children (breast) were fit to estimate Odds Ratios (OR) and 95% Confidence Intervals (95% CI).Results Occupational exposure to each of the studied metals was associated with higher prostate cancer risk. Associations were specially observed for a duration higher than 10 years, and among those working in occupations with higher probability*intensity of the exposure. Working in occupations entailing higher probability*intensity of the exposure to cadmium, chromium and nickel was associated with breast cancer. Arsenic exposure for more than 10 years showed a non-significant higher risk of colorectal cancer. None of the metals assessed showed any suggestion of an association with CLL, nor stomach cancer.Our results support the association between occupational exposure to carcinogenic metals and risk of hormone related tumours like breast and prostate cancer.