RT Journal Article
SR Electronic
T1 P035 Female white collar workers remain at high risk of breast cancer after adjustment for individual risk factors related to reproduction and lifestyle
JF Occupational and Environmental Medicine
JO Occup Environ Med
FD BMJ Publishing Group Ltd
SP A132
OP A132
DO 10.1136/oemed-2016-103951.360
VO 73
IS Suppl 1
A1 Kullberg, Cecilia
A1 Selander, Jenny
A1 Wiebert, Pernilla
A1 Albin, Maria
A1 Borgqvist, Signe
A1 Plato, Nils
A1 Manjer, Jonas
A1 Gustavsson, Per
YR 2016
UL http://oem.bmj.com/content/73/Suppl_1/A132.1.abstract
AB Background Breast cancer is the most common cancer in women worldwide and the incidence is steadily increasing in Sweden. Hormones play an important role in breast cancer aetiology and many of the established risk factors are related to endocrine change in the body. Previous studies have shown differences in breast cancer risk between occupational groups, although without the possibility to control for reproductive and lifestyle factors.Aim The aim was to investigate how much of variation in breast cancer incidence between occupations that could be explained by risk factors related to reproduction and lifestyle.Method Data for this study was obtained from the Malmö Diet and Cancer study, a population cohort study. 14 109 women, born 1923–1950, were followed from 1991–2013. Self-administered questionnaires were answered in regard to lifestyle and reproductive risk factors. Hazard ratios were estimated for occupational groups and compared with and without adjustments for reproductive and lifestyle factors.Preliminary results White collar workers were at higher risk of breast cancer than blue collar workers. After adjusting for reproductive and lifestyle risk factors the risk for white collar workers were decreased while the risks for blue collar workers were increased. Registered nurses had a significantly higher risk of breast cancer, (HR = 1.48 95% CI = 1.07–2.05) also after adjusting for confounding factors, (HR = 1.49 95% CI = 1.07–2.08) compared to all other occupations. Teachers in theoretical subjects had a higher risk of breast cancer (HR = 1.57 95% CI = 1.06–2.32) in the crude model which decreased after adjustments (HR = 1.35 95% CI = 0.89–2.05), indicating that the excess risk were caused by reproductive and lifestyle risk factors.Conclusion Female white collar workers, including registered nurses, remain at high risk of breast cancer after adjustment for individual risk factors related to reproduction and lifestyle.